Genmab — Maj 2021

JørgenVarnæs

Det giver mening

E_L

agree with GB. Epco is so potent, you only need minimal amounts

E_L

that is why i hoped for the same with hexacd38, and Jan's answer was in the same direction: 'At this moment we are testing different doses of HexaBody Cd38 in mm patients. If the
efficacy follows the very promising preclinical profile it may indeed be possible to use
3 / 6
Q&A GENMAB
17TH OF MAY 2021
WITH JAN VAN DE WINKEL
far lower doses than with daratumumab. If that follows from the clinical testing, we
may be able to dose subcutaneously without hyaluronidase in deed.'

E_L

my queston was exactly on that 'do you anticipate that Hexabody-CD38 could
potentially be given subcutaneous (without the need for eg. Halozyme)?'

JørgenVarnæs

Nice! Thx EL

Bulder

Nogen SH-tal?

Bulder

Ingen tvivl om at det afgørende spm ved hexa38 er tåleligheden. Når man i sin tid var skeptiske ved dara, skyldes det at cd38 findes overalt i kroppen. Så med et endnu mere potent stof, kan det måske volde problemer.

Bulder

JV 11.35: Kesimpta gives med autoinjektor med 20 mg. Dara Faspro er 1800 mg. Det gør en forskel, som nødvendiggør hyaluronidase, som får dara til at ligge i et reservoir under huden, så det optages langsomt.

Bulder

Det har i øvrigt vist sig at give færre bivirkninger end IV, selv om denne indgives over mange timer.

E_L

Gilead’s Magrolimab is an Investigational Anti-CD47 Monoclonal Antibody- in new trial with a.o. Dara here for MM
https://clinicaltrials.gov/ct2/show/NCT04892446 (just after Sukkeralf asked Jan about the Blink cooperation...)

E_L

lol, new trial: Blenrep in combi with Dara - https://clinicaltrials.gov/ct2/show/NCT04892264

E_L

AbbVie to Showcase Breadth of Oncology Portfolio and Pipeline at the 2021 ASCO https://news.abbvie.com/news/press-releases/abbvie-to-showcase-breadth-oncology-portfolio-and-pipeline-at-2021-asco-and-eha-annual-congresses.htm

E_L

it seems they forgot epco at EHA

Bulder

Yes, Blenrep, once a threat, now a partner. They all want to make friends with dara.

E_L

Bulder

Stadig ingen SH-tal?

E_L

@_Hubrecht
&
@Genmab
received the Galien Excellence COVID-19 Award for the STRIP-1 SARS-CoV-2 testing robot https://twitter.com/oncodeinstitute/status/1395003349028773892

GeorgeBest

E L, when do you have the ASCO abstracts for us?

E_L

Helge is absent today because he needs to sleep whole day; he will need the whole night to prepare summaries for us for tomorrow morning 60 Dara abstracts lol

GeorgeBest

Dara abstracts are boring I am more interested in the next winner...