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Genmab — Maj 2021

Planlagt Fastgjort Låst Flyttet Genmab
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  • G Offline
    G Offline
    GeorgeBest
    wrote on sidst redigeret af
    #746

    Jo

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    • JørgenVarnæsJ Offline
      JørgenVarnæsJ Offline
      JørgenVarnæs
      wrote on sidst redigeret af
      #747

      Hmm - her er vist et område, vi kan tage op ved næste PI Chat med GEN

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      • G Offline
        G Offline
        GeorgeBest
        wrote on sidst redigeret af
        #748

        HALO er ikke med indover epco!

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        • B Offline
          B Offline
          BioShare
          wrote on sidst redigeret af
          #749

          I givet fald sorry - jeg var ret overbevist om at HALO var inde over.

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          • JørgenVarnæsJ Offline
            JørgenVarnæsJ Offline
            JørgenVarnæs
            wrote on sidst redigeret af
            #750

            Kesimplta bliver også beskrevet som SubQ- og dem har halo vist ikke været inde over

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            • JørgenVarnæsJ Offline
              JørgenVarnæsJ Offline
              JørgenVarnæs
              wrote on sidst redigeret af
              #751

              ..men jeg har ikke hørt om revenue cuts/royalties på hverken kesimpta eller epco

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              • G Offline
                G Offline
                GeorgeBest
                wrote on sidst redigeret af
                #752

                Det er tidligere blevet beskrevet, at HALO ikke behøves p.g.a. de små doseringer...

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                • JørgenVarnæsJ Offline
                  JørgenVarnæsJ Offline
                  JørgenVarnæs
                  wrote on sidst redigeret af
                  #753

                  Det giver mening

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                  • E Offline
                    E Offline
                    E_L
                    wrote on sidst redigeret af
                    #754

                    agree with GB. Epco is so potent, you only need minimal amounts

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                    • E Offline
                      E Offline
                      E_L
                      wrote on sidst redigeret af
                      #755

                      that is why i hoped for the same with hexacd38, and Jan's answer was in the same direction: 'At this moment we are testing different doses of HexaBody Cd38 in mm patients. If the
                      efficacy follows the very promising preclinical profile it may indeed be possible to use
                      3 / 6
                      Q&A GENMAB
                      17TH OF MAY 2021
                      WITH JAN VAN DE WINKEL
                      far lower doses than with daratumumab. If that follows from the clinical testing, we
                      may be able to dose subcutaneously without hyaluronidase in deed.'

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                      • E Offline
                        E Offline
                        E_L
                        wrote on sidst redigeret af
                        #756

                        my queston was exactly on that 'do you anticipate that Hexabody-CD38 could
                        potentially be given subcutaneous (without the need for eg. Halozyme)?'

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                        • JørgenVarnæsJ Offline
                          JørgenVarnæsJ Offline
                          JørgenVarnæs
                          wrote on sidst redigeret af
                          #757

                          Nice! Thx EL

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                          • BulderB Offline
                            BulderB Offline
                            Bulder
                            wrote on sidst redigeret af
                            #758

                            Nogen SH-tal?

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                            • BulderB Offline
                              BulderB Offline
                              Bulder
                              wrote on sidst redigeret af
                              #759

                              Ingen tvivl om at det afgørende spm ved hexa38 er tåleligheden. Når man i sin tid var skeptiske ved dara, skyldes det at cd38 findes overalt i kroppen. Så med et endnu mere potent stof, kan det måske volde problemer.

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                              • BulderB Offline
                                BulderB Offline
                                Bulder
                                wrote on sidst redigeret af
                                #760

                                JV 11.35: Kesimpta gives med autoinjektor med 20 mg. Dara Faspro er 1800 mg. Det gør en forskel, som nødvendiggør hyaluronidase, som får dara til at ligge i et reservoir under huden, så det optages langsomt.

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                                • BulderB Offline
                                  BulderB Offline
                                  Bulder
                                  wrote on sidst redigeret af
                                  #761

                                  Det har i øvrigt vist sig at give færre bivirkninger end IV, selv om denne indgives over mange timer.

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                                  • E Offline
                                    E Offline
                                    E_L
                                    wrote on sidst redigeret af
                                    #762

                                    Gilead’s Magrolimab is an Investigational Anti-CD47 Monoclonal Antibody- in new trial with a.o. Dara here for MM
                                    https://clinicaltrials.gov/ct2/show/NCT04892446 (just after Sukkeralf asked Jan about the Blink cooperation...)

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                                    • E Offline
                                      E Offline
                                      E_L
                                      wrote on sidst redigeret af
                                      #763

                                      lol, new trial: Blenrep in combi with Dara - https://clinicaltrials.gov/ct2/show/NCT04892264

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                                      • E Offline
                                        E Offline
                                        E_L
                                        wrote on sidst redigeret af
                                        #764

                                        AbbVie to Showcase Breadth of Oncology Portfolio and Pipeline at the 2021 ASCO https://news.abbvie.com/news/press-releases/abbvie-to-showcase-breadth-oncology-portfolio-and-pipeline-at-2021-asco-and-eha-annual-congresses.htm

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                                        • E Offline
                                          E Offline
                                          E_L
                                          wrote on sidst redigeret af
                                          #765

                                          it seems they forgot epco at EHA 😉

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