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Genmab — Maj 2021

Planlagt Fastgjort Låst Flyttet Genmab
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  • G Offline
    G Offline
    GeorgeBest
    wrote on sidst redigeret af
    #748

    HALO er ikke med indover epco!

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    • B Offline
      B Offline
      BioShare
      wrote on sidst redigeret af
      #749

      I givet fald sorry - jeg var ret overbevist om at HALO var inde over.

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      • JørgenVarnæsJ Offline
        JørgenVarnæsJ Offline
        JørgenVarnæs
        wrote on sidst redigeret af
        #750

        Kesimplta bliver også beskrevet som SubQ- og dem har halo vist ikke været inde over

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        • JørgenVarnæsJ Offline
          JørgenVarnæsJ Offline
          JørgenVarnæs
          wrote on sidst redigeret af
          #751

          ..men jeg har ikke hørt om revenue cuts/royalties på hverken kesimpta eller epco

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          • G Offline
            G Offline
            GeorgeBest
            wrote on sidst redigeret af
            #752

            Det er tidligere blevet beskrevet, at HALO ikke behøves p.g.a. de små doseringer...

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            • JørgenVarnæsJ Offline
              JørgenVarnæsJ Offline
              JørgenVarnæs
              wrote on sidst redigeret af
              #753

              Det giver mening

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              • E Offline
                E Offline
                E_L
                wrote on sidst redigeret af
                #754

                agree with GB. Epco is so potent, you only need minimal amounts

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                • E Offline
                  E Offline
                  E_L
                  wrote on sidst redigeret af
                  #755

                  that is why i hoped for the same with hexacd38, and Jan's answer was in the same direction: 'At this moment we are testing different doses of HexaBody Cd38 in mm patients. If the
                  efficacy follows the very promising preclinical profile it may indeed be possible to use
                  3 / 6
                  Q&A GENMAB
                  17TH OF MAY 2021
                  WITH JAN VAN DE WINKEL
                  far lower doses than with daratumumab. If that follows from the clinical testing, we
                  may be able to dose subcutaneously without hyaluronidase in deed.'

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                  • E Offline
                    E Offline
                    E_L
                    wrote on sidst redigeret af
                    #756

                    my queston was exactly on that 'do you anticipate that Hexabody-CD38 could
                    potentially be given subcutaneous (without the need for eg. Halozyme)?'

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                    • JørgenVarnæsJ Offline
                      JørgenVarnæsJ Offline
                      JørgenVarnæs
                      wrote on sidst redigeret af
                      #757

                      Nice! Thx EL

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                      • BulderB Offline
                        BulderB Offline
                        Bulder
                        wrote on sidst redigeret af
                        #758

                        Nogen SH-tal?

                        1 Reply Last reply
                        0
                        • BulderB Offline
                          BulderB Offline
                          Bulder
                          wrote on sidst redigeret af
                          #759

                          Ingen tvivl om at det afgørende spm ved hexa38 er tåleligheden. Når man i sin tid var skeptiske ved dara, skyldes det at cd38 findes overalt i kroppen. Så med et endnu mere potent stof, kan det måske volde problemer.

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                          • BulderB Offline
                            BulderB Offline
                            Bulder
                            wrote on sidst redigeret af
                            #760

                            JV 11.35: Kesimpta gives med autoinjektor med 20 mg. Dara Faspro er 1800 mg. Det gør en forskel, som nødvendiggør hyaluronidase, som får dara til at ligge i et reservoir under huden, så det optages langsomt.

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                            • BulderB Offline
                              BulderB Offline
                              Bulder
                              wrote on sidst redigeret af
                              #761

                              Det har i øvrigt vist sig at give færre bivirkninger end IV, selv om denne indgives over mange timer.

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                              • E Offline
                                E Offline
                                E_L
                                wrote on sidst redigeret af
                                #762

                                Gilead’s Magrolimab is an Investigational Anti-CD47 Monoclonal Antibody- in new trial with a.o. Dara here for MM
                                https://clinicaltrials.gov/ct2/show/NCT04892446 (just after Sukkeralf asked Jan about the Blink cooperation...)

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                                • E Offline
                                  E Offline
                                  E_L
                                  wrote on sidst redigeret af
                                  #763

                                  lol, new trial: Blenrep in combi with Dara - https://clinicaltrials.gov/ct2/show/NCT04892264

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                                  • E Offline
                                    E Offline
                                    E_L
                                    wrote on sidst redigeret af
                                    #764

                                    AbbVie to Showcase Breadth of Oncology Portfolio and Pipeline at the 2021 ASCO https://news.abbvie.com/news/press-releases/abbvie-to-showcase-breadth-oncology-portfolio-and-pipeline-at-2021-asco-and-eha-annual-congresses.htm

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                                    • E Offline
                                      E Offline
                                      E_L
                                      wrote on sidst redigeret af
                                      #765

                                      it seems they forgot epco at EHA 😉

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                                      • BulderB Offline
                                        BulderB Offline
                                        Bulder
                                        wrote on sidst redigeret af
                                        #766

                                        Yes, Blenrep, once a threat, now a partner. They all want to make friends with dara.

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                                        • E Offline
                                          E Offline
                                          E_L
                                          wrote on sidst redigeret af
                                          #767

                                          😉

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                                          0

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