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Genmab — Maj 2021

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
  • G Offline
    G Offline
    GeorgeBest
    wrote on sidst redigeret af
    #752

    Det er tidligere blevet beskrevet, at HALO ikke behøves p.g.a. de små doseringer...

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    • JørgenVarnæsJ Offline
      JørgenVarnæsJ Offline
      JørgenVarnæs
      wrote on sidst redigeret af
      #753

      Det giver mening

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      • E Offline
        E Offline
        E_L
        wrote on sidst redigeret af
        #754

        agree with GB. Epco is so potent, you only need minimal amounts

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        • E Offline
          E Offline
          E_L
          wrote on sidst redigeret af
          #755

          that is why i hoped for the same with hexacd38, and Jan's answer was in the same direction: 'At this moment we are testing different doses of HexaBody Cd38 in mm patients. If the
          efficacy follows the very promising preclinical profile it may indeed be possible to use
          3 / 6
          Q&A GENMAB
          17TH OF MAY 2021
          WITH JAN VAN DE WINKEL
          far lower doses than with daratumumab. If that follows from the clinical testing, we
          may be able to dose subcutaneously without hyaluronidase in deed.'

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          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #756

            my queston was exactly on that 'do you anticipate that Hexabody-CD38 could
            potentially be given subcutaneous (without the need for eg. Halozyme)?'

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            • JørgenVarnæsJ Offline
              JørgenVarnæsJ Offline
              JørgenVarnæs
              wrote on sidst redigeret af
              #757

              Nice! Thx EL

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              • BulderB Offline
                BulderB Offline
                Bulder
                wrote on sidst redigeret af
                #758

                Nogen SH-tal?

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                • BulderB Offline
                  BulderB Offline
                  Bulder
                  wrote on sidst redigeret af
                  #759

                  Ingen tvivl om at det afgørende spm ved hexa38 er tåleligheden. Når man i sin tid var skeptiske ved dara, skyldes det at cd38 findes overalt i kroppen. Så med et endnu mere potent stof, kan det måske volde problemer.

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                  • BulderB Offline
                    BulderB Offline
                    Bulder
                    wrote on sidst redigeret af
                    #760

                    JV 11.35: Kesimpta gives med autoinjektor med 20 mg. Dara Faspro er 1800 mg. Det gør en forskel, som nødvendiggør hyaluronidase, som får dara til at ligge i et reservoir under huden, så det optages langsomt.

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                    • BulderB Offline
                      BulderB Offline
                      Bulder
                      wrote on sidst redigeret af
                      #761

                      Det har i øvrigt vist sig at give færre bivirkninger end IV, selv om denne indgives over mange timer.

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                      • E Offline
                        E Offline
                        E_L
                        wrote on sidst redigeret af
                        #762

                        Gilead’s Magrolimab is an Investigational Anti-CD47 Monoclonal Antibody- in new trial with a.o. Dara here for MM
                        https://clinicaltrials.gov/ct2/show/NCT04892446 (just after Sukkeralf asked Jan about the Blink cooperation...)

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                        • E Offline
                          E Offline
                          E_L
                          wrote on sidst redigeret af
                          #763

                          lol, new trial: Blenrep in combi with Dara - https://clinicaltrials.gov/ct2/show/NCT04892264

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                          • E Offline
                            E Offline
                            E_L
                            wrote on sidst redigeret af
                            #764

                            AbbVie to Showcase Breadth of Oncology Portfolio and Pipeline at the 2021 ASCO https://news.abbvie.com/news/press-releases/abbvie-to-showcase-breadth-oncology-portfolio-and-pipeline-at-2021-asco-and-eha-annual-congresses.htm

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                            • E Offline
                              E Offline
                              E_L
                              wrote on sidst redigeret af
                              #765

                              it seems they forgot epco at EHA 😉

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                              • BulderB Offline
                                BulderB Offline
                                Bulder
                                wrote on sidst redigeret af
                                #766

                                Yes, Blenrep, once a threat, now a partner. They all want to make friends with dara.

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                                • E Offline
                                  E Offline
                                  E_L
                                  wrote on sidst redigeret af
                                  #767

                                  😉

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                                  • BulderB Offline
                                    BulderB Offline
                                    Bulder
                                    wrote on sidst redigeret af
                                    #768

                                    Stadig ingen SH-tal?

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                                    • E Offline
                                      E Offline
                                      E_L
                                      wrote on sidst redigeret af
                                      #769

                                      @_Hubrecht
                                      &
                                      @Genmab
                                      received the Galien Excellence COVID-19 Award for the STRIP-1 SARS-CoV-2 testing robot https://twitter.com/oncodeinstitute/status/1395003349028773892

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                                      • G Offline
                                        G Offline
                                        GeorgeBest
                                        wrote on sidst redigeret af
                                        #770

                                        E L, when do you have the ASCO abstracts for us? 😉

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                                        • E Offline
                                          E Offline
                                          E_L
                                          wrote on sidst redigeret af
                                          #771

                                          😄 Helge is absent today because he needs to sleep whole day; he will need the whole night to prepare summaries for us for tomorrow morning 😉 60 Dara abstracts lol

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