Genmab — Maj 2021

[Bulder]

Ingen tvivl om at det afgørende spm ved hexa38 er tåleligheden. Når man i sin tid var skeptiske ved dara, skyldes det at cd38 findes overalt i kroppen. Så med et endnu mere potent stof, kan det måske volde problemer.

[Bulder]

JV 11.35: Kesimpta gives med autoinjektor med 20 mg. Dara Faspro er 1800 mg. Det gør en forskel, som nødvendiggør hyaluronidase, som får dara til at ligge i et reservoir under huden, så det optages langsomt.

[Bulder]

Det har i øvrigt vist sig at give færre bivirkninger end IV, selv om denne indgives over mange timer.

[E_L]

Gilead’s Magrolimab is an Investigational Anti-CD47 Monoclonal Antibody- in new trial with a.o. Dara here for MM
https://clinicaltrials.gov/ct2/show/NCT04892446 (just after Sukkeralf asked Jan about the Blink cooperation...)

[E_L]

lol, new trial: Blenrep in combi with Dara - https://clinicaltrials.gov/ct2/show/NCT04892264

[E_L]

AbbVie to Showcase Breadth of Oncology Portfolio and Pipeline at the 2021 ASCO https://news.abbvie.com/news/press-releases/abbvie-to-showcase-breadth-oncology-portfolio-and-pipeline-at-2021-asco-and-eha-annual-congresses.htm

[E_L]

it seems they forgot epco at EHA

[Bulder]

Yes, Blenrep, once a threat, now a partner. They all want to make friends with dara.

[E_L]

[Bulder]

Stadig ingen SH-tal?

[E_L]

@_Hubrecht
&
@Genmab
received the Galien Excellence COVID-19 Award for the STRIP-1 SARS-CoV-2 testing robot https://twitter.com/oncodeinstitute/status/1395003349028773892

[GeorgeBest]

E L, when do you have the ASCO abstracts for us?

[E_L]

Helge is absent today because he needs to sleep whole day; he will need the whole night to prepare summaries for us for tomorrow morning 60 Dara abstracts lol

[GeorgeBest]

Dara abstracts are boring I am more interested in the next winner...

[E_L]

I am sure Helge will categorise them appropriately

[Helge_LarsenPI-redaktør]

Sorry. I've been busy all day with podcasts and video production. Darzalex April was $ 298M. Increase of just over 10% as there were 2 working days less compared to March.

[E_L]

But I think we have see all the epco data we will get in the EHA abstract this week tbh

[E_L]

thanks Helge; solid number; next month over

300

[GeorgeBest]

Okay E L. I just had this comment in mind from Jan, and it was related to ASCO: „ Let us start with our own product candidates. There will be an important presentation on epco data from the initial Phase I/II study. This presentation will highlight the promise and success of our DuoBody platform..“

[E_L]

i know, but the EHA and ASCO abstract had to be sent in around the same time, so the data can not be (much) different i think. They may elaborate with a bit of an update again in June, during the presentation though?