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Genmab — Maj 2021

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
  • B Offline
    B Offline
    BioShare
    wrote on sidst redigeret af
    #749

    I givet fald sorry - jeg var ret overbevist om at HALO var inde over.

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    • JørgenVarnæsJ Offline
      JørgenVarnæsJ Offline
      JørgenVarnæs
      wrote on sidst redigeret af
      #750

      Kesimplta bliver også beskrevet som SubQ- og dem har halo vist ikke været inde over

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      • JørgenVarnæsJ Offline
        JørgenVarnæsJ Offline
        JørgenVarnæs
        wrote on sidst redigeret af
        #751

        ..men jeg har ikke hørt om revenue cuts/royalties på hverken kesimpta eller epco

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        • G Offline
          G Offline
          GeorgeBest
          wrote on sidst redigeret af
          #752

          Det er tidligere blevet beskrevet, at HALO ikke behøves p.g.a. de små doseringer...

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          • JørgenVarnæsJ Offline
            JørgenVarnæsJ Offline
            JørgenVarnæs
            wrote on sidst redigeret af
            #753

            Det giver mening

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            • E Offline
              E Offline
              E_L
              wrote on sidst redigeret af
              #754

              agree with GB. Epco is so potent, you only need minimal amounts

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              • E Offline
                E Offline
                E_L
                wrote on sidst redigeret af
                #755

                that is why i hoped for the same with hexacd38, and Jan's answer was in the same direction: 'At this moment we are testing different doses of HexaBody Cd38 in mm patients. If the
                efficacy follows the very promising preclinical profile it may indeed be possible to use
                3 / 6
                Q&A GENMAB
                17TH OF MAY 2021
                WITH JAN VAN DE WINKEL
                far lower doses than with daratumumab. If that follows from the clinical testing, we
                may be able to dose subcutaneously without hyaluronidase in deed.'

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                • E Offline
                  E Offline
                  E_L
                  wrote on sidst redigeret af
                  #756

                  my queston was exactly on that 'do you anticipate that Hexabody-CD38 could
                  potentially be given subcutaneous (without the need for eg. Halozyme)?'

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                  • JørgenVarnæsJ Offline
                    JørgenVarnæsJ Offline
                    JørgenVarnæs
                    wrote on sidst redigeret af
                    #757

                    Nice! Thx EL

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                    • BulderB Offline
                      BulderB Offline
                      Bulder
                      wrote on sidst redigeret af
                      #758

                      Nogen SH-tal?

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                      • BulderB Offline
                        BulderB Offline
                        Bulder
                        wrote on sidst redigeret af
                        #759

                        Ingen tvivl om at det afgørende spm ved hexa38 er tåleligheden. Når man i sin tid var skeptiske ved dara, skyldes det at cd38 findes overalt i kroppen. Så med et endnu mere potent stof, kan det måske volde problemer.

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                        • BulderB Offline
                          BulderB Offline
                          Bulder
                          wrote on sidst redigeret af
                          #760

                          JV 11.35: Kesimpta gives med autoinjektor med 20 mg. Dara Faspro er 1800 mg. Det gør en forskel, som nødvendiggør hyaluronidase, som får dara til at ligge i et reservoir under huden, så det optages langsomt.

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                          • BulderB Offline
                            BulderB Offline
                            Bulder
                            wrote on sidst redigeret af
                            #761

                            Det har i øvrigt vist sig at give færre bivirkninger end IV, selv om denne indgives over mange timer.

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                            • E Offline
                              E Offline
                              E_L
                              wrote on sidst redigeret af
                              #762

                              Gilead’s Magrolimab is an Investigational Anti-CD47 Monoclonal Antibody- in new trial with a.o. Dara here for MM
                              https://clinicaltrials.gov/ct2/show/NCT04892446 (just after Sukkeralf asked Jan about the Blink cooperation...)

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                              • E Offline
                                E Offline
                                E_L
                                wrote on sidst redigeret af
                                #763

                                lol, new trial: Blenrep in combi with Dara - https://clinicaltrials.gov/ct2/show/NCT04892264

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                                • E Offline
                                  E Offline
                                  E_L
                                  wrote on sidst redigeret af
                                  #764

                                  AbbVie to Showcase Breadth of Oncology Portfolio and Pipeline at the 2021 ASCO https://news.abbvie.com/news/press-releases/abbvie-to-showcase-breadth-oncology-portfolio-and-pipeline-at-2021-asco-and-eha-annual-congresses.htm

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                                  • E Offline
                                    E Offline
                                    E_L
                                    wrote on sidst redigeret af
                                    #765

                                    it seems they forgot epco at EHA 😉

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                                    • BulderB Offline
                                      BulderB Offline
                                      Bulder
                                      wrote on sidst redigeret af
                                      #766

                                      Yes, Blenrep, once a threat, now a partner. They all want to make friends with dara.

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                                      • E Offline
                                        E Offline
                                        E_L
                                        wrote on sidst redigeret af
                                        #767

                                        😉

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                                        • BulderB Offline
                                          BulderB Offline
                                          Bulder
                                          wrote on sidst redigeret af
                                          #768

                                          Stadig ingen SH-tal?

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                                          0

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