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Genmab — November 2017

Planlagt Fastgjort Låst Flyttet Genmab
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  • E Offline
    E Offline
    E_L
    wrote on sidst redigeret af
    #2929

    Interview Usmani: https://www.healio.com/hematology-oncology/education-lab/2017/03_march/multiple-myeloma-central/interview-spotlight-3-saad-z-usmani-md-facp

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    • E Offline
      E Offline
      E_L
      wrote on sidst redigeret af
      #2930

      "In 2017, the standard of care for myeloma is a three-drug combination. The debate about three drugs vs. two drugs is over based on available data."

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      • E Offline
        E Offline
        E_L
        wrote on sidst redigeret af
        #2931

        on Castor / Pollux : "...now have solid data in that regard. We have not seen these kinds of hazard ratios in myeloma clinical trials ever"

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        • P Offline
          P Offline
          Plimsoller
          wrote on sidst redigeret af
          #2932

          Thanks E L. Assume that is good news, but what is meant by "Hazard ratios", and dows that mean the "two drug combination" has won ?

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          • P Offline
            P Offline
            Plimsoller
            wrote on sidst redigeret af
            #2933

            dows = does

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            • B Offline
              B Offline
              bibob
              wrote on sidst redigeret af
              #2934

              No, that means that 3 drugs has won. The three drug combination is more effektive as I understand the article.

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              • E Offline
                E Offline
                E_L
                wrote on sidst redigeret af
                #2935

                yes, 3 wins. A hazard ratio (HR) is a calculation of the ratio of the chance of something harmful happening (such as
                death or cancer recurrence) in one entire treatment group, divided by the risk of the event in the comparison
                treatment group. A HR of 1 means there is no dierence between the groups, a HR of 2 is double the risk and a HR of 0.5 is
                half the risk.

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                • G Offline
                  G Offline
                  gentogen
                  wrote on sidst redigeret af
                  #2936

                  Så med andre ord har man aldrig før set så klare forbedringer

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                  • E Offline
                    E Offline
                    E_L
                    wrote on sidst redigeret af
                    #2937

                    save this on your PC
                    https://moodle2.units.it/pluginfile.php/146715/mod_resource/content/1/understanding_clinical_trials.pdf

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                    • P Offline
                      P Offline
                      Plimsoller
                      wrote on sidst redigeret af
                      #2938

                      Done. Thank you.

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                      • G Offline
                        G Offline
                        gentogen
                        wrote on sidst redigeret af
                        #2939

                        Læg også mærke til, at data er endnu bedre i nyeste abstract. Usmani henviser til en tidligere forbedring fra 43% CR til 46% CR. Den er nu 51% CR. Dara virker bedre og bedre med tiden. Og i øvrigt var allerede de 43% en sensation.

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                        • S Offline
                          S Offline
                          Sukkeralf
                          wrote on sidst redigeret af
                          #2940

                          Ja også derfor det bliver spændende med Alcyone data - måske i morgen og ellers først på ASH

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                          • B Offline
                            B Offline
                            bibob
                            wrote on sidst redigeret af
                            #2941

                            Alletiders hvis de var med i morgen.

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                            • J Offline
                              J Offline
                              JohnW
                              wrote on sidst redigeret af
                              #2942

                              Undskyld, hvad er det der sker i morgen?

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                              • G Offline
                                G Offline
                                GeorgeBest
                                wrote on sidst redigeret af
                                #2943

                                det meddeles hvad der kommer med på ASH some late-breaker. ALCYONE er en kandidat hertil.

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                                • G Offline
                                  G Offline
                                  GeorgeBest
                                  wrote on sidst redigeret af
                                  #2944

                                  Hvis ikke ALCYONE får late-breaker status, vil markedet nok tolke det som negativt. Er der mon lækket noget i dag. Genmab er ned, og markedet er op?

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                                  • J Offline
                                    J Offline
                                    JohnW
                                    wrote on sidst redigeret af
                                    #2945

                                    Så vi får at vide om ALCYONE kommer med eller ej, men vi får vel ikke nogle resultater af ALCYONE i morgen?

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                                    • J Offline
                                      J Offline
                                      JohnW
                                      wrote on sidst redigeret af
                                      #2946

                                      Ok. I see. Så bliver morgendagen jo spændende.

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                                      • P Offline
                                        P Offline
                                        polle1
                                        wrote on sidst redigeret af
                                        #2947

                                        Kommer disse late breaker som en samlet meddelelse, og hvad tid på dagen ?

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                                        • BulderB Offline
                                          BulderB Offline
                                          Bulder
                                          wrote on sidst redigeret af
                                          #2948

                                          Alle 6 mulige abstracts bliver offentliggjort på en gang. Hele abstractet med alle væsentlige data kommer ud. Vel omkring kl. 14 når de står op derovre.

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