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Genmab — November 2017

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
  • E Offline
    E Offline
    E_L
    wrote on sidst redigeret af
    #2930

    "In 2017, the standard of care for myeloma is a three-drug combination. The debate about three drugs vs. two drugs is over based on available data."

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    • E Offline
      E Offline
      E_L
      wrote on sidst redigeret af
      #2931

      on Castor / Pollux : "...now have solid data in that regard. We have not seen these kinds of hazard ratios in myeloma clinical trials ever"

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      • P Offline
        P Offline
        Plimsoller
        wrote on sidst redigeret af
        #2932

        Thanks E L. Assume that is good news, but what is meant by "Hazard ratios", and dows that mean the "two drug combination" has won ?

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        • P Offline
          P Offline
          Plimsoller
          wrote on sidst redigeret af
          #2933

          dows = does

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          • B Offline
            B Offline
            bibob
            wrote on sidst redigeret af
            #2934

            No, that means that 3 drugs has won. The three drug combination is more effektive as I understand the article.

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            • E Offline
              E Offline
              E_L
              wrote on sidst redigeret af
              #2935

              yes, 3 wins. A hazard ratio (HR) is a calculation of the ratio of the chance of something harmful happening (such as
              death or cancer recurrence) in one entire treatment group, divided by the risk of the event in the comparison
              treatment group. A HR of 1 means there is no dierence between the groups, a HR of 2 is double the risk and a HR of 0.5 is
              half the risk.

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              • G Offline
                G Offline
                gentogen
                wrote on sidst redigeret af
                #2936

                Så med andre ord har man aldrig før set så klare forbedringer

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                • E Offline
                  E Offline
                  E_L
                  wrote on sidst redigeret af
                  #2937

                  save this on your PC
                  https://moodle2.units.it/pluginfile.php/146715/mod_resource/content/1/understanding_clinical_trials.pdf

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                  • P Offline
                    P Offline
                    Plimsoller
                    wrote on sidst redigeret af
                    #2938

                    Done. Thank you.

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                    • G Offline
                      G Offline
                      gentogen
                      wrote on sidst redigeret af
                      #2939

                      Læg også mærke til, at data er endnu bedre i nyeste abstract. Usmani henviser til en tidligere forbedring fra 43% CR til 46% CR. Den er nu 51% CR. Dara virker bedre og bedre med tiden. Og i øvrigt var allerede de 43% en sensation.

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                      • S Offline
                        S Offline
                        Sukkeralf
                        wrote on sidst redigeret af
                        #2940

                        Ja også derfor det bliver spændende med Alcyone data - måske i morgen og ellers først på ASH

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                        • B Offline
                          B Offline
                          bibob
                          wrote on sidst redigeret af
                          #2941

                          Alletiders hvis de var med i morgen.

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                          • J Offline
                            J Offline
                            JohnW
                            wrote on sidst redigeret af
                            #2942

                            Undskyld, hvad er det der sker i morgen?

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                            • G Offline
                              G Offline
                              GeorgeBest
                              wrote on sidst redigeret af
                              #2943

                              det meddeles hvad der kommer med på ASH some late-breaker. ALCYONE er en kandidat hertil.

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                              • G Offline
                                G Offline
                                GeorgeBest
                                wrote on sidst redigeret af
                                #2944

                                Hvis ikke ALCYONE får late-breaker status, vil markedet nok tolke det som negativt. Er der mon lækket noget i dag. Genmab er ned, og markedet er op?

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                                • J Offline
                                  J Offline
                                  JohnW
                                  wrote on sidst redigeret af
                                  #2945

                                  Så vi får at vide om ALCYONE kommer med eller ej, men vi får vel ikke nogle resultater af ALCYONE i morgen?

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                                  • J Offline
                                    J Offline
                                    JohnW
                                    wrote on sidst redigeret af
                                    #2946

                                    Ok. I see. Så bliver morgendagen jo spændende.

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                                    • P Offline
                                      P Offline
                                      polle1
                                      wrote on sidst redigeret af
                                      #2947

                                      Kommer disse late breaker som en samlet meddelelse, og hvad tid på dagen ?

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                                      • BulderB Offline
                                        BulderB Offline
                                        Bulder
                                        wrote on sidst redigeret af
                                        #2948

                                        Alle 6 mulige abstracts bliver offentliggjort på en gang. Hele abstractet med alle væsentlige data kommer ud. Vel omkring kl. 14 når de står op derovre.

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                                        • J Offline
                                          J Offline
                                          JohnW
                                          wrote on sidst redigeret af
                                          #2949

                                          Hvis ALCYONE ikke kommer med som late breaker, hvornår får vi så data fra ALCYONE at se?

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