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Genmab — November 2017

Planlagt Fastgjort Låst Flyttet Genmab
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  • O Offline
    O Offline
    OHW
    wrote on sidst redigeret af
    #2928

    Undskyld, fejlpost!

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    • E Offline
      E Offline
      E_L
      wrote on sidst redigeret af
      #2929

      Interview Usmani: https://www.healio.com/hematology-oncology/education-lab/2017/03_march/multiple-myeloma-central/interview-spotlight-3-saad-z-usmani-md-facp

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      • E Offline
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        E_L
        wrote on sidst redigeret af
        #2930

        "In 2017, the standard of care for myeloma is a three-drug combination. The debate about three drugs vs. two drugs is over based on available data."

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        • E Offline
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          E_L
          wrote on sidst redigeret af
          #2931

          on Castor / Pollux : "...now have solid data in that regard. We have not seen these kinds of hazard ratios in myeloma clinical trials ever"

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          • P Offline
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            Plimsoller
            wrote on sidst redigeret af
            #2932

            Thanks E L. Assume that is good news, but what is meant by "Hazard ratios", and dows that mean the "two drug combination" has won ?

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            • P Offline
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              Plimsoller
              wrote on sidst redigeret af
              #2933

              dows = does

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              • B Offline
                B Offline
                bibob
                wrote on sidst redigeret af
                #2934

                No, that means that 3 drugs has won. The three drug combination is more effektive as I understand the article.

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                • E Offline
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                  E_L
                  wrote on sidst redigeret af
                  #2935

                  yes, 3 wins. A hazard ratio (HR) is a calculation of the ratio of the chance of something harmful happening (such as
                  death or cancer recurrence) in one entire treatment group, divided by the risk of the event in the comparison
                  treatment group. A HR of 1 means there is no dierence between the groups, a HR of 2 is double the risk and a HR of 0.5 is
                  half the risk.

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                  • G Offline
                    G Offline
                    gentogen
                    wrote on sidst redigeret af
                    #2936

                    Så med andre ord har man aldrig før set så klare forbedringer

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                    • E Offline
                      E Offline
                      E_L
                      wrote on sidst redigeret af
                      #2937

                      save this on your PC
                      https://moodle2.units.it/pluginfile.php/146715/mod_resource/content/1/understanding_clinical_trials.pdf

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                      • P Offline
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                        Plimsoller
                        wrote on sidst redigeret af
                        #2938

                        Done. Thank you.

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                        • G Offline
                          G Offline
                          gentogen
                          wrote on sidst redigeret af
                          #2939

                          Læg også mærke til, at data er endnu bedre i nyeste abstract. Usmani henviser til en tidligere forbedring fra 43% CR til 46% CR. Den er nu 51% CR. Dara virker bedre og bedre med tiden. Og i øvrigt var allerede de 43% en sensation.

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                          • S Offline
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                            Sukkeralf
                            wrote on sidst redigeret af
                            #2940

                            Ja også derfor det bliver spændende med Alcyone data - måske i morgen og ellers først på ASH

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                            • B Offline
                              B Offline
                              bibob
                              wrote on sidst redigeret af
                              #2941

                              Alletiders hvis de var med i morgen.

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                              • J Offline
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                                JohnW
                                wrote on sidst redigeret af
                                #2942

                                Undskyld, hvad er det der sker i morgen?

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                                • G Offline
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                                  GeorgeBest
                                  wrote on sidst redigeret af
                                  #2943

                                  det meddeles hvad der kommer med på ASH some late-breaker. ALCYONE er en kandidat hertil.

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                                  • G Offline
                                    G Offline
                                    GeorgeBest
                                    wrote on sidst redigeret af
                                    #2944

                                    Hvis ikke ALCYONE får late-breaker status, vil markedet nok tolke det som negativt. Er der mon lækket noget i dag. Genmab er ned, og markedet er op?

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                                    • J Offline
                                      J Offline
                                      JohnW
                                      wrote on sidst redigeret af
                                      #2945

                                      Så vi får at vide om ALCYONE kommer med eller ej, men vi får vel ikke nogle resultater af ALCYONE i morgen?

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                                      • J Offline
                                        J Offline
                                        JohnW
                                        wrote on sidst redigeret af
                                        #2946

                                        Ok. I see. Så bliver morgendagen jo spændende.

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                                        • P Offline
                                          P Offline
                                          polle1
                                          wrote on sidst redigeret af
                                          #2947

                                          Kommer disse late breaker som en samlet meddelelse, og hvad tid på dagen ?

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