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Genmab — November 2017

Planlagt Fastgjort Låst Flyttet Genmab
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  • E Offline
    E Offline
    E_L
    wrote on sidst redigeret af
    #2931

    on Castor / Pollux : "...now have solid data in that regard. We have not seen these kinds of hazard ratios in myeloma clinical trials ever"

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    • P Offline
      P Offline
      Plimsoller
      wrote on sidst redigeret af
      #2932

      Thanks E L. Assume that is good news, but what is meant by "Hazard ratios", and dows that mean the "two drug combination" has won ?

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      • P Offline
        P Offline
        Plimsoller
        wrote on sidst redigeret af
        #2933

        dows = does

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        • B Offline
          B Offline
          bibob
          wrote on sidst redigeret af
          #2934

          No, that means that 3 drugs has won. The three drug combination is more effektive as I understand the article.

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          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #2935

            yes, 3 wins. A hazard ratio (HR) is a calculation of the ratio of the chance of something harmful happening (such as
            death or cancer recurrence) in one entire treatment group, divided by the risk of the event in the comparison
            treatment group. A HR of 1 means there is no dierence between the groups, a HR of 2 is double the risk and a HR of 0.5 is
            half the risk.

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            • G Offline
              G Offline
              gentogen
              wrote on sidst redigeret af
              #2936

              Så med andre ord har man aldrig før set så klare forbedringer

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              • E Offline
                E Offline
                E_L
                wrote on sidst redigeret af
                #2937

                save this on your PC
                https://moodle2.units.it/pluginfile.php/146715/mod_resource/content/1/understanding_clinical_trials.pdf

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                • P Offline
                  P Offline
                  Plimsoller
                  wrote on sidst redigeret af
                  #2938

                  Done. Thank you.

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                  • G Offline
                    G Offline
                    gentogen
                    wrote on sidst redigeret af
                    #2939

                    Læg også mærke til, at data er endnu bedre i nyeste abstract. Usmani henviser til en tidligere forbedring fra 43% CR til 46% CR. Den er nu 51% CR. Dara virker bedre og bedre med tiden. Og i øvrigt var allerede de 43% en sensation.

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                    • S Offline
                      S Offline
                      Sukkeralf
                      wrote on sidst redigeret af
                      #2940

                      Ja også derfor det bliver spændende med Alcyone data - måske i morgen og ellers først på ASH

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                      • B Offline
                        B Offline
                        bibob
                        wrote on sidst redigeret af
                        #2941

                        Alletiders hvis de var med i morgen.

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                        • J Offline
                          J Offline
                          JohnW
                          wrote on sidst redigeret af
                          #2942

                          Undskyld, hvad er det der sker i morgen?

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                          • G Offline
                            G Offline
                            GeorgeBest
                            wrote on sidst redigeret af
                            #2943

                            det meddeles hvad der kommer med på ASH some late-breaker. ALCYONE er en kandidat hertil.

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                            • G Offline
                              G Offline
                              GeorgeBest
                              wrote on sidst redigeret af
                              #2944

                              Hvis ikke ALCYONE får late-breaker status, vil markedet nok tolke det som negativt. Er der mon lækket noget i dag. Genmab er ned, og markedet er op?

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                              • J Offline
                                J Offline
                                JohnW
                                wrote on sidst redigeret af
                                #2945

                                Så vi får at vide om ALCYONE kommer med eller ej, men vi får vel ikke nogle resultater af ALCYONE i morgen?

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                                • J Offline
                                  J Offline
                                  JohnW
                                  wrote on sidst redigeret af
                                  #2946

                                  Ok. I see. Så bliver morgendagen jo spændende.

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                                  • P Offline
                                    P Offline
                                    polle1
                                    wrote on sidst redigeret af
                                    #2947

                                    Kommer disse late breaker som en samlet meddelelse, og hvad tid på dagen ?

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                                    • BulderB Offline
                                      BulderB Offline
                                      Bulder
                                      wrote on sidst redigeret af
                                      #2948

                                      Alle 6 mulige abstracts bliver offentliggjort på en gang. Hele abstractet med alle væsentlige data kommer ud. Vel omkring kl. 14 når de står op derovre.

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                                      • J Offline
                                        J Offline
                                        JohnW
                                        wrote on sidst redigeret af
                                        #2949

                                        Hvis ALCYONE ikke kommer med som late breaker, hvornår får vi så data fra ALCYONE at se?

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                                        • P Offline
                                          P Offline
                                          polle1
                                          wrote on sidst redigeret af
                                          #2950

                                          Mange tak for info, Bulder !

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