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Genmab — November 2017

Planlagt Fastgjort Låst Flyttet Genmab
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    OHW
    wrote on sidst redigeret af
    #2927

    Måske er det JJ der sælger ud?

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    • O Offline
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      OHW
      wrote on sidst redigeret af
      #2928

      Undskyld, fejlpost!

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      • E Offline
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        E_L
        wrote on sidst redigeret af
        #2929

        Interview Usmani: https://www.healio.com/hematology-oncology/education-lab/2017/03_march/multiple-myeloma-central/interview-spotlight-3-saad-z-usmani-md-facp

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        • E Offline
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          E_L
          wrote on sidst redigeret af
          #2930

          "In 2017, the standard of care for myeloma is a three-drug combination. The debate about three drugs vs. two drugs is over based on available data."

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          • E Offline
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            E_L
            wrote on sidst redigeret af
            #2931

            on Castor / Pollux : "...now have solid data in that regard. We have not seen these kinds of hazard ratios in myeloma clinical trials ever"

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              Plimsoller
              wrote on sidst redigeret af
              #2932

              Thanks E L. Assume that is good news, but what is meant by "Hazard ratios", and dows that mean the "two drug combination" has won ?

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              • P Offline
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                Plimsoller
                wrote on sidst redigeret af
                #2933

                dows = does

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                • B Offline
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                  bibob
                  wrote on sidst redigeret af
                  #2934

                  No, that means that 3 drugs has won. The three drug combination is more effektive as I understand the article.

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                  • E Offline
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                    E_L
                    wrote on sidst redigeret af
                    #2935

                    yes, 3 wins. A hazard ratio (HR) is a calculation of the ratio of the chance of something harmful happening (such as
                    death or cancer recurrence) in one entire treatment group, divided by the risk of the event in the comparison
                    treatment group. A HR of 1 means there is no dierence between the groups, a HR of 2 is double the risk and a HR of 0.5 is
                    half the risk.

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                    • G Offline
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                      gentogen
                      wrote on sidst redigeret af
                      #2936

                      Så med andre ord har man aldrig før set så klare forbedringer

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                      • E Offline
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                        E_L
                        wrote on sidst redigeret af
                        #2937

                        save this on your PC
                        https://moodle2.units.it/pluginfile.php/146715/mod_resource/content/1/understanding_clinical_trials.pdf

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                          Plimsoller
                          wrote on sidst redigeret af
                          #2938

                          Done. Thank you.

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                          • G Offline
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                            gentogen
                            wrote on sidst redigeret af
                            #2939

                            Læg også mærke til, at data er endnu bedre i nyeste abstract. Usmani henviser til en tidligere forbedring fra 43% CR til 46% CR. Den er nu 51% CR. Dara virker bedre og bedre med tiden. Og i øvrigt var allerede de 43% en sensation.

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                            • S Offline
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                              Sukkeralf
                              wrote on sidst redigeret af
                              #2940

                              Ja også derfor det bliver spændende med Alcyone data - måske i morgen og ellers først på ASH

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                              • B Offline
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                                bibob
                                wrote on sidst redigeret af
                                #2941

                                Alletiders hvis de var med i morgen.

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                                • J Offline
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                                  JohnW
                                  wrote on sidst redigeret af
                                  #2942

                                  Undskyld, hvad er det der sker i morgen?

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                                  • G Offline
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                                    GeorgeBest
                                    wrote on sidst redigeret af
                                    #2943

                                    det meddeles hvad der kommer med på ASH some late-breaker. ALCYONE er en kandidat hertil.

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                                    • G Offline
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                                      GeorgeBest
                                      wrote on sidst redigeret af
                                      #2944

                                      Hvis ikke ALCYONE får late-breaker status, vil markedet nok tolke det som negativt. Er der mon lækket noget i dag. Genmab er ned, og markedet er op?

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                                      • J Offline
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                                        JohnW
                                        wrote on sidst redigeret af
                                        #2945

                                        Så vi får at vide om ALCYONE kommer med eller ej, men vi får vel ikke nogle resultater af ALCYONE i morgen?

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                                        • J Offline
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                                          JohnW
                                          wrote on sidst redigeret af
                                          #2946

                                          Ok. I see. Så bliver morgendagen jo spændende.

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