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Genmab — November 2017

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
  • B Offline
    B Offline
    bibob
    wrote on sidst redigeret af
    #2925

    Kunne måske blive en interessant lukkeauktion. 😉

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    • A Offline
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      AaBforever
      wrote on sidst redigeret af
      #2926

      A/B nettosalg 46600

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      • O Offline
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        OHW
        wrote on sidst redigeret af
        #2927

        Måske er det JJ der sælger ud?

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        • O Offline
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          OHW
          wrote on sidst redigeret af
          #2928

          Undskyld, fejlpost!

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          • E Offline
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            E_L
            wrote on sidst redigeret af
            #2929

            Interview Usmani: https://www.healio.com/hematology-oncology/education-lab/2017/03_march/multiple-myeloma-central/interview-spotlight-3-saad-z-usmani-md-facp

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            • E Offline
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              E_L
              wrote on sidst redigeret af
              #2930

              "In 2017, the standard of care for myeloma is a three-drug combination. The debate about three drugs vs. two drugs is over based on available data."

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              • E Offline
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                E_L
                wrote on sidst redigeret af
                #2931

                on Castor / Pollux : "...now have solid data in that regard. We have not seen these kinds of hazard ratios in myeloma clinical trials ever"

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                  Plimsoller
                  wrote on sidst redigeret af
                  #2932

                  Thanks E L. Assume that is good news, but what is meant by "Hazard ratios", and dows that mean the "two drug combination" has won ?

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                  • P Offline
                    P Offline
                    Plimsoller
                    wrote on sidst redigeret af
                    #2933

                    dows = does

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                    • B Offline
                      B Offline
                      bibob
                      wrote on sidst redigeret af
                      #2934

                      No, that means that 3 drugs has won. The three drug combination is more effektive as I understand the article.

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                      • E Offline
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                        E_L
                        wrote on sidst redigeret af
                        #2935

                        yes, 3 wins. A hazard ratio (HR) is a calculation of the ratio of the chance of something harmful happening (such as
                        death or cancer recurrence) in one entire treatment group, divided by the risk of the event in the comparison
                        treatment group. A HR of 1 means there is no dierence between the groups, a HR of 2 is double the risk and a HR of 0.5 is
                        half the risk.

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                        • G Offline
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                          gentogen
                          wrote on sidst redigeret af
                          #2936

                          Så med andre ord har man aldrig før set så klare forbedringer

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                          • E Offline
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                            E_L
                            wrote on sidst redigeret af
                            #2937

                            save this on your PC
                            https://moodle2.units.it/pluginfile.php/146715/mod_resource/content/1/understanding_clinical_trials.pdf

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                              Plimsoller
                              wrote on sidst redigeret af
                              #2938

                              Done. Thank you.

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                                gentogen
                                wrote on sidst redigeret af
                                #2939

                                Læg også mærke til, at data er endnu bedre i nyeste abstract. Usmani henviser til en tidligere forbedring fra 43% CR til 46% CR. Den er nu 51% CR. Dara virker bedre og bedre med tiden. Og i øvrigt var allerede de 43% en sensation.

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                                • S Offline
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                                  Sukkeralf
                                  wrote on sidst redigeret af
                                  #2940

                                  Ja også derfor det bliver spændende med Alcyone data - måske i morgen og ellers først på ASH

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                                  • B Offline
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                                    bibob
                                    wrote on sidst redigeret af
                                    #2941

                                    Alletiders hvis de var med i morgen.

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                                    • J Offline
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                                      JohnW
                                      wrote on sidst redigeret af
                                      #2942

                                      Undskyld, hvad er det der sker i morgen?

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                                      • G Offline
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                                        GeorgeBest
                                        wrote on sidst redigeret af
                                        #2943

                                        det meddeles hvad der kommer med på ASH some late-breaker. ALCYONE er en kandidat hertil.

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                                        • G Offline
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                                          GeorgeBest
                                          wrote on sidst redigeret af
                                          #2944

                                          Hvis ikke ALCYONE får late-breaker status, vil markedet nok tolke det som negativt. Er der mon lækket noget i dag. Genmab er ned, og markedet er op?

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