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  4. Genmab — Marts 2022

Genmab — Marts 2022

Planlagt Fastgjort Låst Flyttet Genmab
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  • S Offline
    S Offline
    Sukkeralf
    wrote on sidst redigeret af
    #527

    Måske dara kunne indgå i et multispecifikt antistof af en art - eller hexabody for den sags skyld

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    • BulderB Offline
      BulderB Offline
      Bulder
      wrote on sidst redigeret af
      #528

      ja, hvis superdara+tec eller tal bliver en mulighed, ser det stærkt ud.

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      • BulderB Offline
        BulderB Offline
        Bulder
        wrote on sidst redigeret af
        #529

        Men man kunne godt mistænkte JnJ for ikke at have lyst til at bruge penge på superdara, fordi der i forvejen er dara, tec, tal og nu Carvykti.

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        • E Offline
          E Offline
          E_L
          wrote on sidst redigeret af
          #530

          Børsen summary in Medwatch lol https://medwatch.dk/Medicinal___Biotek/article13878824.ece

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          • S Offline
            S Offline
            Sukkeralf
            wrote on sidst redigeret af
            #531

            Ja og problemet er trods alt, at det skal først skal kæmpe med Darzalex off patent og senere Darzalex faspro, så man skal godt nok være god. Chancerne er nok størst hvis det virker i nye indikationer eller i patienter der ikke længere responderer på daratumumab.

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            • E Offline
              E Offline
              E_L
              wrote on sidst redigeret af
              #532

              development from other companies will make competition to Dara stronger and stronger; JNJ will have to keep improving as well . If Hexa is clearly better I find it hard to believe JNJ would not develop it further

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              • E Offline
                E Offline
                E_L
                wrote on sidst redigeret af
                #533

                I would like to know more about the UBS Hex38
                comments

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                • S Offline
                  S Offline
                  Sukkeralf
                  wrote on sidst redigeret af
                  #534

                  EL i would like that too - but is it realistic to expect HexaCD38 to be clearly better than daratumumab. I´m not so sure - so far vi have not seen that many proofs about the hexabody platform in the clinic or interest from partners

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                  • SolsenS Offline
                    SolsenS Offline
                    Solsen
                    wrote on sidst redigeret af
                    #535

                    Vi ved at carvykti er super dyr og besværlig at arbejde med. Økonomisk får JNJ også mindre ud af den aftale end daraaftalen. Så hvis hexa38 kan komme på højde med det stof i effekt og bivirkninger er der ikke noget der taler for, at de ikke hopper på hexa38.

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                    • B Offline
                      B Offline
                      bibob
                      wrote on sidst redigeret af
                      #536

                      De kunne vel i princippet lave aftaler på begge stoffer. ??

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                      • BulderB Offline
                        BulderB Offline
                        Bulder
                        wrote on sidst redigeret af
                        #537

                        Men det er så også noget af en ambition for hex38. ORR på 98%, 78% sCR i 7. linje!

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                        • E Offline
                          E Offline
                          E_L
                          wrote on sidst redigeret af
                          #538

                          @Sukkeralf I was hoping for another hexabody mention in the BionTech presentation but there was none this time. The start of a hexabody trail with them would be nice support for the platform

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                          • S Offline
                            S Offline
                            Sukkeralf
                            wrote on sidst redigeret af
                            #539

                            Yes Jan has promissed us that so hopefully its only a few months away

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                            • S Offline
                              S Offline
                              Sukkeralf
                              wrote on sidst redigeret af
                              #540

                              But still thats not clinical data and we dont now if its a new or old target

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                              • S Offline
                                S Offline
                                Sukkeralf
                                wrote on sidst redigeret af
                                #541

                                It was Momenta Pharmaceuticals Janssen bought:

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                                0
                                • S Offline
                                  S Offline
                                  Sukkeralf
                                  wrote on sidst redigeret af
                                  #542

                                  Link Preview Image
                                  Post Page

                                  Authentic, fact-based healthcare content writing services.

                                  favicon

                                  (bareskymarketing.com)

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                                  • S Offline
                                    S Offline
                                    Sukkeralf
                                    wrote on sidst redigeret af
                                    #543

                                    M267: a SIFbody candidate targeting CD38

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                                    • BulderB Offline
                                      BulderB Offline
                                      Bulder
                                      wrote on sidst redigeret af
                                      #544

                                      SIFbody er åbenbart noget hexabody-agtigt, (multimerization). Mere potent end dara. Bedre til at aktivere CDC. Så en direkte konkurrent til superdara. https://aacrjournals.org/cancerres/article/79/13_Supplement/561/637257/Abstract-561-Discovery-of-a-potential-best-in

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                                      • SolsenS Offline
                                        SolsenS Offline
                                        Solsen
                                        wrote on sidst redigeret af
                                        #545

                                        En 3 år gammel poster. Hvor står M267 i dag ?

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                                        • SolsenS Offline
                                          SolsenS Offline
                                          Solsen
                                          wrote on sidst redigeret af
                                          #546

                                          Jeg kan ikke finde noget på stoffet efter medio 2020.

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