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  4. Genmab — Marts 2022

Genmab — Marts 2022

Planlagt Fastgjort Låst Flyttet Genmab
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  • S Offline
    S Offline
    Sukkeralf
    wrote on sidst redigeret af
    #526

    Ja og de bispecifikke antistoffer

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    • S Offline
      S Offline
      Sukkeralf
      wrote on sidst redigeret af
      #527

      Måske dara kunne indgå i et multispecifikt antistof af en art - eller hexabody for den sags skyld

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      • BulderB Offline
        BulderB Offline
        Bulder
        wrote on sidst redigeret af
        #528

        ja, hvis superdara+tec eller tal bliver en mulighed, ser det stærkt ud.

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        • BulderB Offline
          BulderB Offline
          Bulder
          wrote on sidst redigeret af
          #529

          Men man kunne godt mistænkte JnJ for ikke at have lyst til at bruge penge på superdara, fordi der i forvejen er dara, tec, tal og nu Carvykti.

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          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #530

            Børsen summary in Medwatch lol https://medwatch.dk/Medicinal___Biotek/article13878824.ece

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            • S Offline
              S Offline
              Sukkeralf
              wrote on sidst redigeret af
              #531

              Ja og problemet er trods alt, at det skal først skal kæmpe med Darzalex off patent og senere Darzalex faspro, så man skal godt nok være god. Chancerne er nok størst hvis det virker i nye indikationer eller i patienter der ikke længere responderer på daratumumab.

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              • E Offline
                E Offline
                E_L
                wrote on sidst redigeret af
                #532

                development from other companies will make competition to Dara stronger and stronger; JNJ will have to keep improving as well . If Hexa is clearly better I find it hard to believe JNJ would not develop it further

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                • E Offline
                  E Offline
                  E_L
                  wrote on sidst redigeret af
                  #533

                  I would like to know more about the UBS Hex38
                  comments

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                  • S Offline
                    S Offline
                    Sukkeralf
                    wrote on sidst redigeret af
                    #534

                    EL i would like that too - but is it realistic to expect HexaCD38 to be clearly better than daratumumab. I´m not so sure - so far vi have not seen that many proofs about the hexabody platform in the clinic or interest from partners

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                    • SolsenS Offline
                      SolsenS Offline
                      Solsen
                      wrote on sidst redigeret af
                      #535

                      Vi ved at carvykti er super dyr og besværlig at arbejde med. Økonomisk får JNJ også mindre ud af den aftale end daraaftalen. Så hvis hexa38 kan komme på højde med det stof i effekt og bivirkninger er der ikke noget der taler for, at de ikke hopper på hexa38.

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                      • B Offline
                        B Offline
                        bibob
                        wrote on sidst redigeret af
                        #536

                        De kunne vel i princippet lave aftaler på begge stoffer. ??

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                        • BulderB Offline
                          BulderB Offline
                          Bulder
                          wrote on sidst redigeret af
                          #537

                          Men det er så også noget af en ambition for hex38. ORR på 98%, 78% sCR i 7. linje!

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                          • E Offline
                            E Offline
                            E_L
                            wrote on sidst redigeret af
                            #538

                            @Sukkeralf I was hoping for another hexabody mention in the BionTech presentation but there was none this time. The start of a hexabody trail with them would be nice support for the platform

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                            • S Offline
                              S Offline
                              Sukkeralf
                              wrote on sidst redigeret af
                              #539

                              Yes Jan has promissed us that so hopefully its only a few months away

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                              • S Offline
                                S Offline
                                Sukkeralf
                                wrote on sidst redigeret af
                                #540

                                But still thats not clinical data and we dont now if its a new or old target

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                                0
                                • S Offline
                                  S Offline
                                  Sukkeralf
                                  wrote on sidst redigeret af
                                  #541

                                  It was Momenta Pharmaceuticals Janssen bought:

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                                  • S Offline
                                    S Offline
                                    Sukkeralf
                                    wrote on sidst redigeret af
                                    #542

                                    Link Preview Image
                                    Post Page

                                    Authentic, fact-based healthcare content writing services.

                                    favicon

                                    (bareskymarketing.com)

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                                    • S Offline
                                      S Offline
                                      Sukkeralf
                                      wrote on sidst redigeret af
                                      #543

                                      M267: a SIFbody candidate targeting CD38

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                                      • BulderB Offline
                                        BulderB Offline
                                        Bulder
                                        wrote on sidst redigeret af
                                        #544

                                        SIFbody er åbenbart noget hexabody-agtigt, (multimerization). Mere potent end dara. Bedre til at aktivere CDC. Så en direkte konkurrent til superdara. https://aacrjournals.org/cancerres/article/79/13_Supplement/561/637257/Abstract-561-Discovery-of-a-potential-best-in

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                                        • SolsenS Offline
                                          SolsenS Offline
                                          Solsen
                                          wrote on sidst redigeret af
                                          #545

                                          En 3 år gammel poster. Hvor står M267 i dag ?

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