Genmab — Februar 2019

[JørgenVarnæs]

I guess you have to hope for the latter if you are looking for protection

[Sukkeralf]

But solids will be followed with sc dara and patent protection will be around 2033-2035 so they could get on the marked for some years at least

[Sukkeralf]

But again solids are dead according to Jan

[E_L]

ok, clear. yes, i know Jan said that. At the same time i feel we never got a very good explanation of what really were the issues in those trials; it left me feeling that possibly with other combinations results could be different. But probably pure fiction pure fiction in my head...

[JørgenVarnæs]

JV on things that are dead. Especially dara in solids: https://www.youtube.com/watch?v=yR5Z4n1TdSI

[Sukkeralf]

E L on the other hand we only have preclinical work that says it might work ! Jan has promissed us data from the Carina study that never came and also data from solid study and we have never seen that either. When things goes wrong people are usually not that keen on presenting

[E_L]

yes, very true…

[Bulder]

Studies in dara-nivo in solids will read out this year. You never know.

[Sukkeralf]

But did BMs stop the dara arm in these trials ?

[Bulder]

They stopped recruiting prematurely in one of them. We haven't heard of anything in the two others.

[Bulder]

No, you are right. Enrollment was stopped in the dara-arm in Checkmate358.

[Bulder]

Checkmate142 is not recruiting in general. But the dara-arm has not been specifically changed.

[bibob]

Ninlaro bliver ikke godkendt til vedligeholdelse. https://medwatch.dk/Medicinal___Biotek/article11168756.ece?utm_campaign=MedWatch Middag&utm_content=2019-02-06_B&utm_medium=email&utm_source=medwatch

[Relax]

Tak for svar angående mit spørgsmål om dividende og opkøbsprogram. Er enig at investeringer i egen pipeline er det bedste for aktionærerne. På den anden side er tre år med stagnerende/negativt afkast, en negativt vurderet pipeline (min menning) og et dyrt warrants program, ikke det bedste for aktionærerne. Tænkte derfor at Genmab bliver nød til at komme med andent end eventuelle blockbustere engang i fremtiden.

[E_L]

for the library: Mechanism of Action and Novel IMiD-Based Compounds
and Combinations in Multiple Myeloma https://sci-hub.tw/10.1097/ppo.0000000000000354

[E_L]

Are 4-Drug Regimens Here to Stay? Role in Induction
and Salvage Therapies https://sci-hub.tw/10.1097/ppo.0000000000000351

[Bulder]

Here to stay? Yes, but who shall pay?

[E_L]

[Bulder]

Now we are at it. We haven't heard of any submission for approval of Cassiopeia-regimen. D-VTd. 3½ months since we saw top line.

[peter12]

Har du et kvalificeret gæt ?