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Genmab — Februar 2019

Planlagt Fastgjort Låst Flyttet Genmab
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  • S Offline
    S Offline
    Sukkeralf
    wrote on sidst redigeret af
    #380

    But again solids are dead according to Jan

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    • E Offline
      E Offline
      E_L
      wrote on sidst redigeret af
      #381

      ok, clear. yes, i know Jan said that. At the same time i feel we never got a very good explanation of what really were the issues in those trials; it left me feeling that possibly with other combinations results could be different. But probably pure fiction pure fiction in my head...

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      • JørgenVarnæsJ Offline
        JørgenVarnæsJ Offline
        JørgenVarnæs
        wrote on sidst redigeret af
        #382

        JV on things that are dead. Especially dara in solids: https://www.youtube.com/watch?v=yR5Z4n1TdSI

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        • S Offline
          S Offline
          Sukkeralf
          wrote on sidst redigeret af
          #383

          E L on the other hand we only have preclinical work that says it might work ! Jan has promissed us data from the Carina study that never came and also data from solid study and we have never seen that either. When things goes wrong people are usually not that keen on presenting

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          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #384

            yes, very true…

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            • BulderB Offline
              BulderB Offline
              Bulder
              wrote on sidst redigeret af
              #385

              Studies in dara-nivo in solids will read out this year. You never know.

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              • S Offline
                S Offline
                Sukkeralf
                wrote on sidst redigeret af
                #386

                But did BMs stop the dara arm in these trials ?

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                • BulderB Offline
                  BulderB Offline
                  Bulder
                  wrote on sidst redigeret af
                  #387

                  They stopped recruiting prematurely in one of them. We haven't heard of anything in the two others.

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                  • BulderB Offline
                    BulderB Offline
                    Bulder
                    wrote on sidst redigeret af
                    #388

                    No, you are right. Enrollment was stopped in the dara-arm in Checkmate358.

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                    • BulderB Offline
                      BulderB Offline
                      Bulder
                      wrote on sidst redigeret af
                      #389

                      Checkmate142 is not recruiting in general. But the dara-arm has not been specifically changed.

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                      • B Offline
                        B Offline
                        bibob
                        wrote on sidst redigeret af
                        #390

                        Ninlaro bliver ikke godkendt til vedligeholdelse. https://medwatch.dk/Medicinal___Biotek/article11168756.ece?utm_campaign=MedWatch Middag&utm_content=2019-02-06_B&utm_medium=email&utm_source=medwatch

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                        • R Offline
                          R Offline
                          Relax
                          wrote on sidst redigeret af
                          #391

                          Tak for svar angående mit spørgsmål om dividende og opkøbsprogram. Er enig at investeringer i egen pipeline er det bedste for aktionærerne. På den anden side er tre år med stagnerende/negativt afkast, en negativt vurderet pipeline (min menning) og et dyrt warrants program, ikke det bedste for aktionærerne. Tænkte derfor at Genmab bliver nød til at komme med andent end eventuelle blockbustere engang i fremtiden.

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                          • E Offline
                            E Offline
                            E_L
                            wrote on sidst redigeret af
                            #392

                            for the library: Mechanism of Action and Novel IMiD-Based Compounds
                            and Combinations in Multiple Myeloma https://sci-hub.tw/10.1097/ppo.0000000000000354

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                            • E Offline
                              E Offline
                              E_L
                              wrote on sidst redigeret af
                              #393

                              Are 4-Drug Regimens Here to Stay? Role in Induction
                              and Salvage Therapies https://sci-hub.tw/10.1097/ppo.0000000000000351

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                              • BulderB Offline
                                BulderB Offline
                                Bulder
                                wrote on sidst redigeret af
                                #394

                                Here to stay? Yes, but who shall pay?

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                                • E Offline
                                  E Offline
                                  E_L
                                  wrote on sidst redigeret af
                                  #395

                                  😉

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                                  • BulderB Offline
                                    BulderB Offline
                                    Bulder
                                    wrote on sidst redigeret af
                                    #396

                                    Now we are at it. We haven't heard of any submission for approval of Cassiopeia-regimen. D-VTd. 3½ months since we saw top line.

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                                    • P Offline
                                      P Offline
                                      peter12
                                      wrote on sidst redigeret af
                                      #397

                                      Har du et kvalificeret gæt ?

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                                      • BulderB Offline
                                        BulderB Offline
                                        Bulder
                                        wrote on sidst redigeret af
                                        #398

                                        I forbindelse med patentsnakken for lidt siden: Ser lige at Celgene også har patent på Thalidomid, som udløber i 2023 i US og 2019 i Europa. Det kan jo undre, da Thalidomid er et tudsegammelt oprindeligt tysk stof. Hvem husker ikke skandalen i 50'erne. Men Celgene har åbenbart lavet en så anderledes ny formulering, at de har kunnet opnå ny patent. https://www.sec.gov/Archives/edgar/data/816284/000095012310055985/filename1.htm

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                                        • BulderB Offline
                                          BulderB Offline
                                          Bulder
                                          wrote on sidst redigeret af
                                          #399

                                          Men det betyder i hvert fald at D-VTd bliver en ret billig kvadruplet om få år.

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