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Genmab — Februar 2019

Planlagt Fastgjort Låst Flyttet Genmab
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  • E Offline
    E Offline
    E_L
    wrote on sidst redigeret af
    #374

    i always am 😉

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    • E Offline
      E Offline
      E_L
      wrote on sidst redigeret af
      #375

      maybe a stupid question, but imagine, in a few years time, IF Dara is found to work in solids; will that allow JNJ to ask a renewed patent for application in solid (and thus a longer time as the current patent life in MM?)

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      • JørgenVarnæsJ Offline
        JørgenVarnæsJ Offline
        JørgenVarnæs
        wrote on sidst redigeret af
        #376

        I guess you have to make the distinction between market and patent protection

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        • JørgenVarnæsJ Offline
          JørgenVarnæsJ Offline
          JørgenVarnæs
          wrote on sidst redigeret af
          #377

          the patent is valid from the point it is granted - and that has nothing to do with the indication. FDA can grant orphan drug status and give you market protection

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          • JørgenVarnæsJ Offline
            JørgenVarnæsJ Offline
            JørgenVarnæs
            wrote on sidst redigeret af
            #378

            I guess you have to hope for the latter if you are looking for protection

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            • S Offline
              S Offline
              Sukkeralf
              wrote on sidst redigeret af
              #379

              But solids will be followed with sc dara and patent protection will be around 2033-2035 so they could get on the marked for some years at least

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              • S Offline
                S Offline
                Sukkeralf
                wrote on sidst redigeret af
                #380

                But again solids are dead according to Jan

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                • E Offline
                  E Offline
                  E_L
                  wrote on sidst redigeret af
                  #381

                  ok, clear. yes, i know Jan said that. At the same time i feel we never got a very good explanation of what really were the issues in those trials; it left me feeling that possibly with other combinations results could be different. But probably pure fiction pure fiction in my head...

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                  • JørgenVarnæsJ Offline
                    JørgenVarnæsJ Offline
                    JørgenVarnæs
                    wrote on sidst redigeret af
                    #382

                    JV on things that are dead. Especially dara in solids: https://www.youtube.com/watch?v=yR5Z4n1TdSI

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                    • S Offline
                      S Offline
                      Sukkeralf
                      wrote on sidst redigeret af
                      #383

                      E L on the other hand we only have preclinical work that says it might work ! Jan has promissed us data from the Carina study that never came and also data from solid study and we have never seen that either. When things goes wrong people are usually not that keen on presenting

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                      • E Offline
                        E Offline
                        E_L
                        wrote on sidst redigeret af
                        #384

                        yes, very true…

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                        • BulderB Offline
                          BulderB Offline
                          Bulder
                          wrote on sidst redigeret af
                          #385

                          Studies in dara-nivo in solids will read out this year. You never know.

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                          • S Offline
                            S Offline
                            Sukkeralf
                            wrote on sidst redigeret af
                            #386

                            But did BMs stop the dara arm in these trials ?

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                            • BulderB Offline
                              BulderB Offline
                              Bulder
                              wrote on sidst redigeret af
                              #387

                              They stopped recruiting prematurely in one of them. We haven't heard of anything in the two others.

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                              • BulderB Offline
                                BulderB Offline
                                Bulder
                                wrote on sidst redigeret af
                                #388

                                No, you are right. Enrollment was stopped in the dara-arm in Checkmate358.

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                                • BulderB Offline
                                  BulderB Offline
                                  Bulder
                                  wrote on sidst redigeret af
                                  #389

                                  Checkmate142 is not recruiting in general. But the dara-arm has not been specifically changed.

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                                  • B Offline
                                    B Offline
                                    bibob
                                    wrote on sidst redigeret af
                                    #390

                                    Ninlaro bliver ikke godkendt til vedligeholdelse. https://medwatch.dk/Medicinal___Biotek/article11168756.ece?utm_campaign=MedWatch Middag&utm_content=2019-02-06_B&utm_medium=email&utm_source=medwatch

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                                    • R Offline
                                      R Offline
                                      Relax
                                      wrote on sidst redigeret af
                                      #391

                                      Tak for svar angående mit spørgsmål om dividende og opkøbsprogram. Er enig at investeringer i egen pipeline er det bedste for aktionærerne. På den anden side er tre år med stagnerende/negativt afkast, en negativt vurderet pipeline (min menning) og et dyrt warrants program, ikke det bedste for aktionærerne. Tænkte derfor at Genmab bliver nød til at komme med andent end eventuelle blockbustere engang i fremtiden.

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                                      • E Offline
                                        E Offline
                                        E_L
                                        wrote on sidst redigeret af
                                        #392

                                        for the library: Mechanism of Action and Novel IMiD-Based Compounds
                                        and Combinations in Multiple Myeloma https://sci-hub.tw/10.1097/ppo.0000000000000354

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                                        • E Offline
                                          E Offline
                                          E_L
                                          wrote on sidst redigeret af
                                          #393

                                          Are 4-Drug Regimens Here to Stay? Role in Induction
                                          and Salvage Therapies https://sci-hub.tw/10.1097/ppo.0000000000000351

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