Genmab — Maj 2021

E_L

my queston was exactly on that 'do you anticipate that Hexabody-CD38 could
potentially be given subcutaneous (without the need for eg. Halozyme)?'

JørgenVarnæs

Nice! Thx EL

Bulder

Nogen SH-tal?

Bulder

Ingen tvivl om at det afgørende spm ved hexa38 er tåleligheden. Når man i sin tid var skeptiske ved dara, skyldes det at cd38 findes overalt i kroppen. Så med et endnu mere potent stof, kan det måske volde problemer.

Bulder

JV 11.35: Kesimpta gives med autoinjektor med 20 mg. Dara Faspro er 1800 mg. Det gør en forskel, som nødvendiggør hyaluronidase, som får dara til at ligge i et reservoir under huden, så det optages langsomt.

Bulder

Det har i øvrigt vist sig at give færre bivirkninger end IV, selv om denne indgives over mange timer.

E_L

Gilead’s Magrolimab is an Investigational Anti-CD47 Monoclonal Antibody- in new trial with a.o. Dara here for MM
https://clinicaltrials.gov/ct2/show/NCT04892446 (just after Sukkeralf asked Jan about the Blink cooperation...)

E_L

lol, new trial: Blenrep in combi with Dara - https://clinicaltrials.gov/ct2/show/NCT04892264

E_L

AbbVie to Showcase Breadth of Oncology Portfolio and Pipeline at the 2021 ASCO https://news.abbvie.com/news/press-releases/abbvie-to-showcase-breadth-oncology-portfolio-and-pipeline-at-2021-asco-and-eha-annual-congresses.htm

E_L

it seems they forgot epco at EHA

Bulder

Yes, Blenrep, once a threat, now a partner. They all want to make friends with dara.

E_L

Bulder

Stadig ingen SH-tal?

E_L

@_Hubrecht
&
@Genmab
received the Galien Excellence COVID-19 Award for the STRIP-1 SARS-CoV-2 testing robot https://twitter.com/oncodeinstitute/status/1395003349028773892

GeorgeBest

E L, when do you have the ASCO abstracts for us?

E_L

Helge is absent today because he needs to sleep whole day; he will need the whole night to prepare summaries for us for tomorrow morning 60 Dara abstracts lol

GeorgeBest

Dara abstracts are boring I am more interested in the next winner...

E_L

I am sure Helge will categorise them appropriately

Helge_LarsenPI-redaktør

Sorry. I've been busy all day with podcasts and video production. Darzalex April was $ 298M. Increase of just over 10% as there were 2 working days less compared to March.

E_L

But I think we have see all the epco data we will get in the EHA abstract this week tbh