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Genmab — December 2019

Planlagt Fastgjort Låst Flyttet Genmab
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  • BulderB Offline
    BulderB Offline
    Bulder
    wrote on sidst redigeret af
    #370

    Det er også det Nina Shah taler om 3 min inde https://www.youtube.com/watch?v=6pbWhqladhQ&feature=youtu.be

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    0
    • SolsenS Offline
      SolsenS Offline
      Solsen
      wrote on sidst redigeret af
      #371

      Flotte data, men SAE kan være et problem. Godt nok spændende hvad Genmabs CD3 arm kan.

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      0
      • SolsenS Offline
        SolsenS Offline
        Solsen
        wrote on sidst redigeret af
        #372

        Vi fandt vel aldrig ud af om det er den berømte silenced arm, der benyttes i JNJs duobodies ?

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        • BulderB Offline
          BulderB Offline
          Bulder
          wrote on sidst redigeret af
          #373

          Det er det vist ikke. Og det er fc-delen der bliver "silenced". Winkel skrev sidste år på q&a: You are referring to the way we have "silenced" the Fc-part of this bispecific. This has
          been done in a novel manner with the intent of lessening interactions with immune
          cells, resulting in less/absent non-specific activation of immune killer cells. This should
          result in better safety.

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          0
          • BulderB Offline
            BulderB Offline
            Bulder
            wrote on sidst redigeret af
            #374

            Det var om cd3xcd20.

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            0
            • BulderB Offline
              BulderB Offline
              Bulder
              wrote on sidst redigeret af
              #375

              Der er mange der arbejder med silencing af fc-regionen. Både for at styrke effekten og for (som i genmabs tilfælde) at mindske bivirkninger. Hvis man googler "silencing fc-domaine" får man masser af hits.

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              • SolsenS Offline
                SolsenS Offline
                Solsen
                wrote on sidst redigeret af
                #376

                Blev der ikke spurgt direkte til om det var denne arm JNJs duobodies havde. Mener at huske han svarede at han ikke kunne afsløre det. Men ikke sikkert, at min hukommelse er god nok -:)

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                • BulderB Offline
                  BulderB Offline
                  Bulder
                  wrote on sidst redigeret af
                  #377

                  Denne her "novel manner" kunne tyde på at Genmab har fundet på noget særligt.

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                  • SolsenS Offline
                    SolsenS Offline
                    Solsen
                    wrote on sidst redigeret af
                    #378

                    Ja. Det bliver spændende.

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                    0
                    • BulderB Offline
                      BulderB Offline
                      Bulder
                      wrote on sidst redigeret af
                      #379

                      Til gengæld har både PD-L1x4-1BB og CD40x4-1BB en form for silenced fc-domæne. Sikkert det samme som cd3xcd20. De har i hvert fald conditional T-cell activation.

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                      0
                      • Helge_LarsenPI-redaktørH Offline
                        Helge_LarsenPI-redaktørH Offline
                        Helge_LarsenPI-redaktør
                        wrote on sidst redigeret af
                        #380

                        Go morgen. 🙂

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                        0
                        • Helge_LarsenPI-redaktørH Offline
                          Helge_LarsenPI-redaktørH Offline
                          Helge_LarsenPI-redaktør
                          wrote on sidst redigeret af
                          #381

                          Update on MAIA study also provided as a poster. PFS still very good 68%) at 3 years. Even with Rd it was a median of 34. Effect of risk less clear on this dataset, although lower numbers.
                          https://twitter.com/Rfonsi1/status/1203433426101125120

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                          • Helge_LarsenPI-redaktørH Offline
                            Helge_LarsenPI-redaktørH Offline
                            Helge_LarsenPI-redaktør
                            wrote on sidst redigeret af
                            #382

                            Rafael Fonseca MD
                            @Rfonsi1
                            ·
                            7 t
                            KEY PAPER. Updated FU on POLUX presented by @kaufman_MMdoc
                            . After a median FU of 59 months the median PFS reported at 45 months. Interestingly TTNT not reached after 63 months. https://twitter.com/Rfonsi1/status/1203437275213967377

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                            0
                            • Helge_LarsenPI-redaktørH Offline
                              Helge_LarsenPI-redaktørH Offline
                              Helge_LarsenPI-redaktør
                              wrote on sidst redigeret af
                              #383

                              The Debate Heats Up Over Treating High Risk Smoldering Multiple Myeloma
                              https://paper.li/Myeloma_Doc/1310386431?read=https%3A%2F%2Fwww.myelomacrowd.org%2Fash-2019-the-debate-heats-up-over-treating-high-risk-smoldering-multiple-myeloma%2F

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                              0
                              • B Offline
                                B Offline
                                bibob
                                wrote on sidst redigeret af
                                #384

                                Just a moment...

                                favicon

                                (www.onclive.com)

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                                0
                                • B Offline
                                  B Offline
                                  bibob
                                  wrote on sidst redigeret af
                                  #385

                                  Landgren previews pivotal ASH 2019 Myeloma data. https://www.onclive.com/conference-coverage/ash-2019/landgren-previews-pivotal-ash-2019-myeloma-data

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                                  0
                                  • S Offline
                                    S Offline
                                    Sukkeralf
                                    wrote on sidst redigeret af
                                    #386

                                    Just a moment...

                                    favicon

                                    (www.firstwordpharma.com)

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                                    0
                                    • S Offline
                                      S Offline
                                      Sukkeralf
                                      wrote on sidst redigeret af
                                      #387

                                      Bulder - "novel manner" skal nok i lige så høj grad se i lyset af at det kunne patenteres.

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                                      • Helge_LarsenPI-redaktørH Offline
                                        Helge_LarsenPI-redaktørH Offline
                                        Helge_LarsenPI-redaktør
                                        wrote on sidst redigeret af
                                        #388

                                        Tak bibo. Landgren giver en god oversigt.

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                                        0
                                        • BulderB Offline
                                          BulderB Offline
                                          Bulder
                                          wrote on sidst redigeret af
                                          #389

                                          Simpelthen utrolige responsrater i JNJ-4528 car-t. ORR 100%, 66% sCR og samme pt-population som Sirius.

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