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Genmab — December 2019

Planlagt Fastgjort Låst Flyttet Genmab
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  • BulderB Offline
    BulderB Offline
    Bulder
    wrote on sidst redigeret af
    #365

    Jo, indtil videre kan vi ikke sige andet end at vi skal holde øje med det. Det kan også være at Takeda vælger at droppe det, som det skete med mor202. Især hvis hex-cd38 viser tænder.

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    • E Offline
      E Offline
      E_L
      wrote on sidst redigeret af
      #366

      I am really curious if Jan can say something substantial about hex-cd38 next monday... As there is only a poster presentation it will have to come from the R&D meeting. Making anohter comment like he did in the Q&A regarding solids would be very welcome here, specially if he can add some substance to those claims

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      • SolsenS Offline
        SolsenS Offline
        Solsen
        wrote on sidst redigeret af
        #367

        https://twitter.com/andrew02114/status/1203340313248632833 Hvad mon dette er...

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        • SolsenS Offline
          SolsenS Offline
          Solsen
          wrote on sidst redigeret af
          #368

          BCMAxCD3 https://www.onclive.com/conference-coverage/ash-2019/anti-bcma-cd3-agent-cc-93269-shows-promise-for-heavily-pretreated-myeloma/

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          • BulderB Offline
            BulderB Offline
            Bulder
            wrote on sidst redigeret af
            #369

            Eller her: https://ash.confex.com/ash/2019/webprogram/Paper122895.html

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            • BulderB Offline
              BulderB Offline
              Bulder
              wrote on sidst redigeret af
              #370

              Det er også det Nina Shah taler om 3 min inde https://www.youtube.com/watch?v=6pbWhqladhQ&feature=youtu.be

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              • SolsenS Offline
                SolsenS Offline
                Solsen
                wrote on sidst redigeret af
                #371

                Flotte data, men SAE kan være et problem. Godt nok spændende hvad Genmabs CD3 arm kan.

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                • SolsenS Offline
                  SolsenS Offline
                  Solsen
                  wrote on sidst redigeret af
                  #372

                  Vi fandt vel aldrig ud af om det er den berømte silenced arm, der benyttes i JNJs duobodies ?

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                  • BulderB Offline
                    BulderB Offline
                    Bulder
                    wrote on sidst redigeret af
                    #373

                    Det er det vist ikke. Og det er fc-delen der bliver "silenced". Winkel skrev sidste år på q&a: You are referring to the way we have "silenced" the Fc-part of this bispecific. This has
                    been done in a novel manner with the intent of lessening interactions with immune
                    cells, resulting in less/absent non-specific activation of immune killer cells. This should
                    result in better safety.

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                    • BulderB Offline
                      BulderB Offline
                      Bulder
                      wrote on sidst redigeret af
                      #374

                      Det var om cd3xcd20.

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                      • BulderB Offline
                        BulderB Offline
                        Bulder
                        wrote on sidst redigeret af
                        #375

                        Der er mange der arbejder med silencing af fc-regionen. Både for at styrke effekten og for (som i genmabs tilfælde) at mindske bivirkninger. Hvis man googler "silencing fc-domaine" får man masser af hits.

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                        • SolsenS Offline
                          SolsenS Offline
                          Solsen
                          wrote on sidst redigeret af
                          #376

                          Blev der ikke spurgt direkte til om det var denne arm JNJs duobodies havde. Mener at huske han svarede at han ikke kunne afsløre det. Men ikke sikkert, at min hukommelse er god nok -:)

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                          • BulderB Offline
                            BulderB Offline
                            Bulder
                            wrote on sidst redigeret af
                            #377

                            Denne her "novel manner" kunne tyde på at Genmab har fundet på noget særligt.

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                            • SolsenS Offline
                              SolsenS Offline
                              Solsen
                              wrote on sidst redigeret af
                              #378

                              Ja. Det bliver spændende.

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                              • BulderB Offline
                                BulderB Offline
                                Bulder
                                wrote on sidst redigeret af
                                #379

                                Til gengæld har både PD-L1x4-1BB og CD40x4-1BB en form for silenced fc-domæne. Sikkert det samme som cd3xcd20. De har i hvert fald conditional T-cell activation.

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                                • Helge_LarsenPI-redaktørH Offline
                                  Helge_LarsenPI-redaktørH Offline
                                  Helge_LarsenPI-redaktør
                                  wrote on sidst redigeret af
                                  #380

                                  Go morgen. 🙂

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                                  • Helge_LarsenPI-redaktørH Offline
                                    Helge_LarsenPI-redaktørH Offline
                                    Helge_LarsenPI-redaktør
                                    wrote on sidst redigeret af
                                    #381

                                    Update on MAIA study also provided as a poster. PFS still very good 68%) at 3 years. Even with Rd it was a median of 34. Effect of risk less clear on this dataset, although lower numbers.
                                    https://twitter.com/Rfonsi1/status/1203433426101125120

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                                    • Helge_LarsenPI-redaktørH Offline
                                      Helge_LarsenPI-redaktørH Offline
                                      Helge_LarsenPI-redaktør
                                      wrote on sidst redigeret af
                                      #382

                                      Rafael Fonseca MD
                                      @Rfonsi1
                                      ·
                                      7 t
                                      KEY PAPER. Updated FU on POLUX presented by @kaufman_MMdoc
                                      . After a median FU of 59 months the median PFS reported at 45 months. Interestingly TTNT not reached after 63 months. https://twitter.com/Rfonsi1/status/1203437275213967377

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                                      • Helge_LarsenPI-redaktørH Offline
                                        Helge_LarsenPI-redaktørH Offline
                                        Helge_LarsenPI-redaktør
                                        wrote on sidst redigeret af
                                        #383

                                        The Debate Heats Up Over Treating High Risk Smoldering Multiple Myeloma
                                        https://paper.li/Myeloma_Doc/1310386431?read=https%3A%2F%2Fwww.myelomacrowd.org%2Fash-2019-the-debate-heats-up-over-treating-high-risk-smoldering-multiple-myeloma%2F

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                                        • B Offline
                                          B Offline
                                          bibob
                                          wrote on sidst redigeret af
                                          #384

                                          Just a moment...

                                          favicon

                                          (www.onclive.com)

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