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Genmab — December 2019

Planlagt Fastgjort Låst Flyttet Genmab
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  • BulderB Offline
    BulderB Offline
    Bulder
    wrote on sidst redigeret af
    #374

    Det var om cd3xcd20.

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    0
    • BulderB Offline
      BulderB Offline
      Bulder
      wrote on sidst redigeret af
      #375

      Der er mange der arbejder med silencing af fc-regionen. Både for at styrke effekten og for (som i genmabs tilfælde) at mindske bivirkninger. Hvis man googler "silencing fc-domaine" får man masser af hits.

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      • SolsenS Offline
        SolsenS Offline
        Solsen
        wrote on sidst redigeret af
        #376

        Blev der ikke spurgt direkte til om det var denne arm JNJs duobodies havde. Mener at huske han svarede at han ikke kunne afsløre det. Men ikke sikkert, at min hukommelse er god nok -:)

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        • BulderB Offline
          BulderB Offline
          Bulder
          wrote on sidst redigeret af
          #377

          Denne her "novel manner" kunne tyde på at Genmab har fundet på noget særligt.

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          0
          • SolsenS Offline
            SolsenS Offline
            Solsen
            wrote on sidst redigeret af
            #378

            Ja. Det bliver spændende.

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            0
            • BulderB Offline
              BulderB Offline
              Bulder
              wrote on sidst redigeret af
              #379

              Til gengæld har både PD-L1x4-1BB og CD40x4-1BB en form for silenced fc-domæne. Sikkert det samme som cd3xcd20. De har i hvert fald conditional T-cell activation.

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              • Helge_LarsenPI-redaktørH Offline
                Helge_LarsenPI-redaktørH Offline
                Helge_LarsenPI-redaktør
                wrote on sidst redigeret af
                #380

                Go morgen. 🙂

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                0
                • Helge_LarsenPI-redaktørH Offline
                  Helge_LarsenPI-redaktørH Offline
                  Helge_LarsenPI-redaktør
                  wrote on sidst redigeret af
                  #381

                  Update on MAIA study also provided as a poster. PFS still very good 68%) at 3 years. Even with Rd it was a median of 34. Effect of risk less clear on this dataset, although lower numbers.
                  https://twitter.com/Rfonsi1/status/1203433426101125120

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                  0
                  • Helge_LarsenPI-redaktørH Offline
                    Helge_LarsenPI-redaktørH Offline
                    Helge_LarsenPI-redaktør
                    wrote on sidst redigeret af
                    #382

                    Rafael Fonseca MD
                    @Rfonsi1
                    ·
                    7 t
                    KEY PAPER. Updated FU on POLUX presented by @kaufman_MMdoc
                    . After a median FU of 59 months the median PFS reported at 45 months. Interestingly TTNT not reached after 63 months. https://twitter.com/Rfonsi1/status/1203437275213967377

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                    • Helge_LarsenPI-redaktørH Offline
                      Helge_LarsenPI-redaktørH Offline
                      Helge_LarsenPI-redaktør
                      wrote on sidst redigeret af
                      #383

                      The Debate Heats Up Over Treating High Risk Smoldering Multiple Myeloma
                      https://paper.li/Myeloma_Doc/1310386431?read=https%3A%2F%2Fwww.myelomacrowd.org%2Fash-2019-the-debate-heats-up-over-treating-high-risk-smoldering-multiple-myeloma%2F

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                      • B Offline
                        B Offline
                        bibob
                        wrote on sidst redigeret af
                        #384

                        Just a moment...

                        favicon

                        (www.onclive.com)

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                        0
                        • B Offline
                          B Offline
                          bibob
                          wrote on sidst redigeret af
                          #385

                          Landgren previews pivotal ASH 2019 Myeloma data. https://www.onclive.com/conference-coverage/ash-2019/landgren-previews-pivotal-ash-2019-myeloma-data

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                          0
                          • S Offline
                            S Offline
                            Sukkeralf
                            wrote on sidst redigeret af
                            #386

                            Just a moment...

                            favicon

                            (www.firstwordpharma.com)

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                            0
                            • S Offline
                              S Offline
                              Sukkeralf
                              wrote on sidst redigeret af
                              #387

                              Bulder - "novel manner" skal nok i lige så høj grad se i lyset af at det kunne patenteres.

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                              0
                              • Helge_LarsenPI-redaktørH Offline
                                Helge_LarsenPI-redaktørH Offline
                                Helge_LarsenPI-redaktør
                                wrote on sidst redigeret af
                                #388

                                Tak bibo. Landgren giver en god oversigt.

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                                0
                                • BulderB Offline
                                  BulderB Offline
                                  Bulder
                                  wrote on sidst redigeret af
                                  #389

                                  Simpelthen utrolige responsrater i JNJ-4528 car-t. ORR 100%, 66% sCR og samme pt-population som Sirius.

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                                  0
                                  • SolsenS Offline
                                    SolsenS Offline
                                    Solsen
                                    wrote on sidst redigeret af
                                    #390

                                    https://twitter.com/jacobplieth/status/1203294761123274754 Data på JNJ-4528

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                                    0
                                    • SolsenS Offline
                                      SolsenS Offline
                                      Solsen
                                      wrote on sidst redigeret af
                                      #391

                                      4-1BB costimulation domain. Måske det er her vejen til succes ligger.

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                                      0
                                      • SolsenS Offline
                                        SolsenS Offline
                                        Solsen
                                        wrote on sidst redigeret af
                                        #392

                                        Stadig et spørgsmål om pris for behandling. Men meget imponerende RR.

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                                        0
                                        • D Offline
                                          D Offline
                                          DevOp
                                          wrote on sidst redigeret af
                                          #393

                                          Stadig nogle voldsomme CRS reaktioner

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