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  4. Genmab — November 2023

Genmab — November 2023

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
  • E Offline
    E Offline
    E_L
    wrote on sidst redigeret af
    #1481

    Also, JNJ have in trial Dara + Teclistamab, which will likely be even better then the Dream 7 combo

    1 Reply Last reply
    0
    • BulderB Offline
      BulderB Offline
      Bulder
      wrote on sidst redigeret af
      #1482

      In Majestec 1 tec+dara had 63% ORR and 39% CR in 4. Line. The ph 3 study is 2.-4. Line.

      1 Reply Last reply
      0
      • BulderB Offline
        BulderB Offline
        Bulder
        wrote on sidst redigeret af
        #1483

        Majestec 3 will probably read out in 2025.

        1 Reply Last reply
        0
        • BulderB Offline
          BulderB Offline
          Bulder
          wrote on sidst redigeret af
          #1484

          https://www.nejm.org/doi/full/10.1056/NEJMoa2203478

          1 Reply Last reply
          0
          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #1485

            Majestec1 was mono I believe, Majestec2 with Dara i think , has data already, need to look it up

            1 Reply Last reply
            0
            • BulderB Offline
              BulderB Offline
              Bulder
              wrote on sidst redigeret af
              #1486

              Yes you are right. Majestec 1 was mono. In Majestec 2: the overall response rate (ORR) was 93.5 percent.1 Among all patients in the trial, VGPRs or better were achieved by 90.3 percent of patients, and 54.8 percent of patients achieved a complete response (CR) or better.

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              • BulderB Offline
                BulderB Offline
                Bulder
                wrote on sidst redigeret af
                #1487

                https://www.jnj.com/janssen-presents-first-data-from-majestec-2-trial-of-tecvayli-teclistamab-cqyv-in-combination-with-darzalex-faspro-daratumumab-and-hyaluronidase-fihj-and-lenalidomide-in-relapsed-or-refractory-multiple-myeloma

                1 Reply Last reply
                0
                • BulderB Offline
                  BulderB Offline
                  Bulder
                  wrote on sidst redigeret af
                  #1488

                  Majestec 2 also combined with lenalidimide. So DR+Tec.

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                  0
                  • BulderB Offline
                    BulderB Offline
                    Bulder
                    wrote on sidst redigeret af
                    #1489

                    Will be hard to beat for bela maf.

                    1 Reply Last reply
                    0
                    • BulderB Offline
                      BulderB Offline
                      Bulder
                      wrote on sidst redigeret af
                      #1490

                      I wonder why GSK didn’t combine bela maf with len.

                      1 Reply Last reply
                      0
                      • E Offline
                        E Offline
                        E_L
                        wrote on sidst redigeret af
                        #1491

                        i think they also have a Ph 1/2 with len. They have more trials , they "Dreamm"
                        a lot 😉

                        1 Reply Last reply
                        0
                        • E Offline
                          E Offline
                          E_L
                          wrote on sidst redigeret af
                          #1492

                          Tisotumab Vedotin Survival Data in Cervical Cancer Are “Game-Changing" https://www.cancernetwork.com/view/tisotumab-vedotin-survival-data-in-cervical-cancer-are-game-changing-

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                          0
                          • E Offline
                            E Offline
                            E_L
                            wrote on sidst redigeret af
                            #1493

                            Trial investigator Brian Slomovitz, MD, Director of Gynecologic Oncology and Co-Chair of the Cancer Research Committee at Mount Sinai Medical Center, discusses results from the global, randomized, open-label Phase 3 innovaTV 301 trial
                            https://www.youtube.com/watch?v=HIZzLVIh15c

                            1 Reply Last reply
                            0
                            • Don_JoningD Offline
                              Don_JoningD Offline
                              Don_Joning
                              wrote on sidst redigeret af
                              #1494

                              Det lyder umiddelbart rigtig godt med Tiso, det er en frygtelig sygdom!

                              1 Reply Last reply
                              0
                              • SolsenS Offline
                                SolsenS Offline
                                Solsen
                                wrote on sidst redigeret af
                                #1495

                                AbbVie will pay $31.26 per share in cash, or approximately $10.1 billion, to acquire ImmunoGen, gaining the antibody-drug conjugate Elahere (mirvetuximab soravtansine).

                                1 Reply Last reply
                                0
                                • SolsenS Offline
                                  SolsenS Offline
                                  Solsen
                                  wrote on sidst redigeret af
                                  #1496

                                  https://finance.yahoo.com/news/abbvie-acquire-immunogen-including-flagship-123000719.html ligner +80-90% i præmium

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                                  0
                                  • SolsenS Offline
                                    SolsenS Offline
                                    Solsen
                                    wrote on sidst redigeret af
                                    #1497

                                    Ingen godkendte stoffer, men et på vej https://investor.immunogen.com/news-releases/news-release-details/immunogen-announces-european-medicines-agency-acceptance

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                                    0
                                    • E Offline
                                      E Offline
                                      E_L
                                      wrote on sidst redigeret af
                                      #1498

                                      I wished you would have told me this yesterday 😉

                                      1 Reply Last reply
                                      0
                                      • K Offline
                                        K Offline
                                        Klarussen
                                        wrote on sidst redigeret af
                                        #1499

                                        Like the lotto numbers 😉

                                        1 Reply Last reply
                                        0
                                        • BulderB Offline
                                          BulderB Offline
                                          Bulder
                                          wrote on sidst redigeret af
                                          #1500

                                          Iflg market wire er præmien 94,7%.

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                                          0

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