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  4. Genmab — November 2023

Genmab — November 2023

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
  • E Offline
    E Offline
    E_L
    wrote on sidst redigeret af
    #1478

    nejm -Amivantamab plus Chemotherapy in NSCLC with EGFR Exon 20 Insertions
    https://www.nejm.org/doi/full/10.1056/NEJMoa2306441

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    • E Offline
      E Offline
      E_L
      wrote on sidst redigeret af
      #1479

      on Blenrep i really need to see the data first; there is a chance some Dara refractory patients were included, which we know would disadvantage the Dara arm in the trial. Need to see if that is the case.

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      • E Offline
        E Offline
        E_L
        wrote on sidst redigeret af
        #1480

        Otherwise it would possibly be more advantageous for Teclistamab then for Blenrep due to Blenrep toxicities.

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        • E Offline
          E Offline
          E_L
          wrote on sidst redigeret af
          #1481

          Also, JNJ have in trial Dara + Teclistamab, which will likely be even better then the Dream 7 combo

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          • BulderB Offline
            BulderB Offline
            Bulder
            wrote on sidst redigeret af
            #1482

            In Majestec 1 tec+dara had 63% ORR and 39% CR in 4. Line. The ph 3 study is 2.-4. Line.

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            • BulderB Offline
              BulderB Offline
              Bulder
              wrote on sidst redigeret af
              #1483

              Majestec 3 will probably read out in 2025.

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              • BulderB Offline
                BulderB Offline
                Bulder
                wrote on sidst redigeret af
                #1484

                Just a moment...

                favicon

                (www.nejm.org)

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                • E Offline
                  E Offline
                  E_L
                  wrote on sidst redigeret af
                  #1485

                  Majestec1 was mono I believe, Majestec2 with Dara i think , has data already, need to look it up

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                  • BulderB Offline
                    BulderB Offline
                    Bulder
                    wrote on sidst redigeret af
                    #1486

                    Yes you are right. Majestec 1 was mono. In Majestec 2: the overall response rate (ORR) was 93.5 percent.1 Among all patients in the trial, VGPRs or better were achieved by 90.3 percent of patients, and 54.8 percent of patients achieved a complete response (CR) or better.

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                    • BulderB Offline
                      BulderB Offline
                      Bulder
                      wrote on sidst redigeret af
                      #1487

                      Site Maintenance

                      favicon

                      (www.jnj.com)

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                      • BulderB Offline
                        BulderB Offline
                        Bulder
                        wrote on sidst redigeret af
                        #1488

                        Majestec 2 also combined with lenalidimide. So DR+Tec.

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                        0
                        • BulderB Offline
                          BulderB Offline
                          Bulder
                          wrote on sidst redigeret af
                          #1489

                          Will be hard to beat for bela maf.

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                          0
                          • BulderB Offline
                            BulderB Offline
                            Bulder
                            wrote on sidst redigeret af
                            #1490

                            I wonder why GSK didn’t combine bela maf with len.

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                            0
                            • E Offline
                              E Offline
                              E_L
                              wrote on sidst redigeret af
                              #1491

                              i think they also have a Ph 1/2 with len. They have more trials , they "Dreamm"
                              a lot 😉

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                              0
                              • E Offline
                                E Offline
                                E_L
                                wrote on sidst redigeret af
                                #1492

                                Tisotumab Vedotin Survival Data in Cervical Cancer Are “Game-Changing" https://www.cancernetwork.com/view/tisotumab-vedotin-survival-data-in-cervical-cancer-are-game-changing-

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                                • E Offline
                                  E Offline
                                  E_L
                                  wrote on sidst redigeret af
                                  #1493

                                  Trial investigator Brian Slomovitz, MD, Director of Gynecologic Oncology and Co-Chair of the Cancer Research Committee at Mount Sinai Medical Center, discusses results from the global, randomized, open-label Phase 3 innovaTV 301 trial
                                  https://www.youtube.com/watch?v=HIZzLVIh15c

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                                  • Don_JoningD Offline
                                    Don_JoningD Offline
                                    Don_Joning
                                    wrote on sidst redigeret af
                                    #1494

                                    Det lyder umiddelbart rigtig godt med Tiso, det er en frygtelig sygdom!

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                                    • SolsenS Offline
                                      SolsenS Offline
                                      Solsen
                                      wrote on sidst redigeret af
                                      #1495

                                      AbbVie will pay $31.26 per share in cash, or approximately $10.1 billion, to acquire ImmunoGen, gaining the antibody-drug conjugate Elahere (mirvetuximab soravtansine).

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                                      • SolsenS Offline
                                        SolsenS Offline
                                        Solsen
                                        wrote on sidst redigeret af
                                        #1496

                                        https://finance.yahoo.com/news/abbvie-acquire-immunogen-including-flagship-123000719.html ligner +80-90% i præmium

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                                        • SolsenS Offline
                                          SolsenS Offline
                                          Solsen
                                          wrote on sidst redigeret af
                                          #1497

                                          Ingen godkendte stoffer, men et på vej https://investor.immunogen.com/news-releases/news-release-details/immunogen-announces-european-medicines-agency-acceptance

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