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  4. Genmab — November 2023

Genmab — November 2023

Planlagt Fastgjort Låst Flyttet Genmab
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  • B Offline
    B Offline
    bibob
    wrote on sidst redigeret af
    #1476

    Blenrep. https://firstwordpharma.com/story/5804061?from=article

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    • B Offline
      B Offline
      bibob
      wrote on sidst redigeret af
      #1477

      https://firstwordpharma.com/story/5804333?from=article

      1 Reply Last reply
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      • E Offline
        E Offline
        E_L
        wrote on sidst redigeret af
        #1478

        nejm -Amivantamab plus Chemotherapy in NSCLC with EGFR Exon 20 Insertions
        https://www.nejm.org/doi/full/10.1056/NEJMoa2306441

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        • E Offline
          E Offline
          E_L
          wrote on sidst redigeret af
          #1479

          on Blenrep i really need to see the data first; there is a chance some Dara refractory patients were included, which we know would disadvantage the Dara arm in the trial. Need to see if that is the case.

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          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #1480

            Otherwise it would possibly be more advantageous for Teclistamab then for Blenrep due to Blenrep toxicities.

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            • E Offline
              E Offline
              E_L
              wrote on sidst redigeret af
              #1481

              Also, JNJ have in trial Dara + Teclistamab, which will likely be even better then the Dream 7 combo

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              • BulderB Offline
                BulderB Offline
                Bulder
                wrote on sidst redigeret af
                #1482

                In Majestec 1 tec+dara had 63% ORR and 39% CR in 4. Line. The ph 3 study is 2.-4. Line.

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                • BulderB Offline
                  BulderB Offline
                  Bulder
                  wrote on sidst redigeret af
                  #1483

                  Majestec 3 will probably read out in 2025.

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                  • BulderB Offline
                    BulderB Offline
                    Bulder
                    wrote on sidst redigeret af
                    #1484

                    Just a moment...

                    favicon

                    (www.nejm.org)

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                    • E Offline
                      E Offline
                      E_L
                      wrote on sidst redigeret af
                      #1485

                      Majestec1 was mono I believe, Majestec2 with Dara i think , has data already, need to look it up

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                      • BulderB Offline
                        BulderB Offline
                        Bulder
                        wrote on sidst redigeret af
                        #1486

                        Yes you are right. Majestec 1 was mono. In Majestec 2: the overall response rate (ORR) was 93.5 percent.1 Among all patients in the trial, VGPRs or better were achieved by 90.3 percent of patients, and 54.8 percent of patients achieved a complete response (CR) or better.

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                        • BulderB Offline
                          BulderB Offline
                          Bulder
                          wrote on sidst redigeret af
                          #1487

                          Site Maintenance

                          favicon

                          (www.jnj.com)

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                          0
                          • BulderB Offline
                            BulderB Offline
                            Bulder
                            wrote on sidst redigeret af
                            #1488

                            Majestec 2 also combined with lenalidimide. So DR+Tec.

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                            0
                            • BulderB Offline
                              BulderB Offline
                              Bulder
                              wrote on sidst redigeret af
                              #1489

                              Will be hard to beat for bela maf.

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                              0
                              • BulderB Offline
                                BulderB Offline
                                Bulder
                                wrote on sidst redigeret af
                                #1490

                                I wonder why GSK didn’t combine bela maf with len.

                                1 Reply Last reply
                                0
                                • E Offline
                                  E Offline
                                  E_L
                                  wrote on sidst redigeret af
                                  #1491

                                  i think they also have a Ph 1/2 with len. They have more trials , they "Dreamm"
                                  a lot 😉

                                  1 Reply Last reply
                                  0
                                  • E Offline
                                    E Offline
                                    E_L
                                    wrote on sidst redigeret af
                                    #1492

                                    Tisotumab Vedotin Survival Data in Cervical Cancer Are “Game-Changing" https://www.cancernetwork.com/view/tisotumab-vedotin-survival-data-in-cervical-cancer-are-game-changing-

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                                    • E Offline
                                      E Offline
                                      E_L
                                      wrote on sidst redigeret af
                                      #1493

                                      Trial investigator Brian Slomovitz, MD, Director of Gynecologic Oncology and Co-Chair of the Cancer Research Committee at Mount Sinai Medical Center, discusses results from the global, randomized, open-label Phase 3 innovaTV 301 trial
                                      https://www.youtube.com/watch?v=HIZzLVIh15c

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                                      • Don_JoningD Offline
                                        Don_JoningD Offline
                                        Don_Joning
                                        wrote on sidst redigeret af
                                        #1494

                                        Det lyder umiddelbart rigtig godt med Tiso, det er en frygtelig sygdom!

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                                        0
                                        • SolsenS Offline
                                          SolsenS Offline
                                          Solsen
                                          wrote on sidst redigeret af
                                          #1495

                                          AbbVie will pay $31.26 per share in cash, or approximately $10.1 billion, to acquire ImmunoGen, gaining the antibody-drug conjugate Elahere (mirvetuximab soravtansine).

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                                          0

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