Genmab — Maj 2020

[E_L]

vaccines...?

[E_L]

BioNTech is trying PD1-/PD-L1
Inhibitors with their mRNA Cancer vaccines in Melanoma; i wonder if this could be an area where the PD-L1x4-1BB duobody could be used instead?

[Sukkeralf]

I Guess so E L based on your comments from the transcript - lots of opportunities going forward with this program if the initial phase I/II data are good

[Sukkeralf]

And both Genmab and BioNTech seems quite thrilled so far - actualy it could be even a bigger product than Darzalex but thats years ahead from now and lots of hills or even mountains to climb

[nohope]

Has anybody ever gotten an approval for a mRNA vaccine ?

[E_L]

no, not yet

[nohope]

Well, I guess this what they call a really long shot in english.

[E_L]

sure. on the other hand, there has never been as much focus and as much research into mRNA as now, due to Covid, surely could lead to something

[nohope]

Yes, really comforting right ? The destiny of the world depends on a technique that has never had a positive outcome.

[E_L]

i am not so sure about that lol, many other trials going on. But , as they say, under pressure everything becomes fluid, let's 'hope' they are successful

[E_L]

the main focus for now for GEN1046
will be solid tumors anyway
.

[nohope]

The Manhattan project of our time ?

[E_L]

that was Daratumumab

[nohope]

A graphite moderated reactor a-la Tjernobyl - fired in the middle of a large town....

[nohope]

Noooo -Dara was done without time pressure - straight

[E_L]

Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors https://www.nature.com/articles/s41591-020-0856-x

[E_L]

full pdf https://sci-hub.tw/https://www.nature.com/articles/s41591-020-0856-x

[AaBforever]

Der bliver handlet igennem i dag. 186 mill. på1 time. Mest omsatte C25.

[AaBforever]

Bestemt. Det ville komme.

[AaBforever]

Suverænt mest omsatte.