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Genmab — Maj 2020

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
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    E_L
    wrote on sidst redigeret af
    #1046

    We believe it has broad potential in a range of solid tumors, including those where checkpoint therapy is currently established but also more difficult tumors where first-generation checkpoint inhibitors have not been as successful. This bispecific antibody has outperformed conventional checkpoint inhibitors in preclinical animal models. We have seen strong evidence in the preclinical setting of its ability to amplify the effect of our vaccines as well."

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    • E Offline
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      E_L
      wrote on sidst redigeret af
      #1047

      vaccines...?

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        E_L
        wrote on sidst redigeret af
        #1048

        BioNTech is trying PD1-/PD-L1
        Inhibitors with their mRNA Cancer vaccines in Melanoma; i wonder if this could be an area where the PD-L1x4-1BB duobody could be used instead?

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          Sukkeralf
          wrote on sidst redigeret af
          #1049

          I Guess so E L based on your comments from the transcript - lots of opportunities going forward with this program if the initial phase I/II data are good

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            Sukkeralf
            wrote on sidst redigeret af
            #1050

            And both Genmab and BioNTech seems quite thrilled so far - actualy it could be even a bigger product than Darzalex but thats years ahead from now and lots of hills or even mountains to climb

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            • nohopeN Offline
              nohopeN Offline
              nohope
              wrote on sidst redigeret af
              #1051

              Has anybody ever gotten an approval for a mRNA vaccine ?

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                E_L
                wrote on sidst redigeret af
                #1052

                no, not yet

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                • nohopeN Offline
                  nohopeN Offline
                  nohope
                  wrote on sidst redigeret af
                  #1053

                  Well, I guess this what they call a really long shot in english.

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                    E_L
                    wrote on sidst redigeret af
                    #1054

                    sure. on the other hand, there has never been as much focus and as much research into mRNA as now, due to Covid, surely could lead to something

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                    • nohopeN Offline
                      nohopeN Offline
                      nohope
                      wrote on sidst redigeret af
                      #1055

                      Yes, really comforting right ? The destiny of the world depends on a technique that has never had a positive outcome.

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                        E_L
                        wrote on sidst redigeret af
                        #1056

                        i am not so sure about that lol, many other trials going on. But , as they say, under pressure everything becomes fluid, let's 'hope' they are successful 😉

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                          E_L
                          wrote on sidst redigeret af
                          #1057

                          the main focus for now for GEN1046
                          will be solid tumors anyway
                          .

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                          • nohopeN Offline
                            nohopeN Offline
                            nohope
                            wrote on sidst redigeret af
                            #1058

                            The Manhattan project of our time ?

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                              E_L
                              wrote on sidst redigeret af
                              #1059

                              that was Daratumumab 😄

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                              • nohopeN Offline
                                nohopeN Offline
                                nohope
                                wrote on sidst redigeret af
                                #1060

                                A graphite moderated reactor a-la Tjernobyl - fired in the middle of a large town....

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                                • nohopeN Offline
                                  nohopeN Offline
                                  nohope
                                  wrote on sidst redigeret af
                                  #1061

                                  Noooo -Dara was done without time pressure - straight

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                                    E_L
                                    wrote on sidst redigeret af
                                    #1062

                                    Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors https://www.nature.com/articles/s41591-020-0856-x

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                                      E_L
                                      wrote on sidst redigeret af
                                      #1063

                                      full pdf https://sci-hub.tw/https://www.nature.com/articles/s41591-020-0856-x

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                                        AaBforever
                                        wrote on sidst redigeret af
                                        #1064

                                        Der bliver handlet igennem i dag. 186 mill. på1 time. Mest omsatte C25.

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                                          AaBforever
                                          wrote on sidst redigeret af
                                          #1065

                                          Bestemt. Det ville komme.

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