Genmab — Maj 2020

[Helge_LarsenPI-redaktør]

dara vs Sarclisa (GEN): https://www.proinvestor.com/debat/84218#84220

[bibob]

Nyt studie med Ofatumumab. ( ARTIOS ) . Ved ikke om det har været postet. https://www.clinicaltrials.gov/ct2/show/NCT04353492?term=Ofatumumab&draw=1&rank=4

[E_L]

From BioNTech SE (BNTX) Q1 2020 Earnings Call Transcript https://www.fool.com/earnings/call-transcripts/2020/05/13/biontech-se-bntx-q1-2020-earnings-call-transcript.aspx

[E_L]

"For our next-generation checkpoint-immune modulatory program partnered with Genmab, the ongoing trial with BNT311, the PD-L1x4-1BB dual body, continues to advance rapidly, as the expansion cohort has been initiated. Data from this Phase 1/2 trial in multiple solid tumors is expected in the second half of this year. We expect the updates to include dose escalation and safety data from the trial. We are excited about this program.

[E_L]

We believe it has broad potential in a range of solid tumors, including those where checkpoint therapy is currently established but also more difficult tumors where first-generation checkpoint inhibitors have not been as successful. This bispecific antibody has outperformed conventional checkpoint inhibitors in preclinical animal models. We have seen strong evidence in the preclinical setting of its ability to amplify the effect of our vaccines as well."

[E_L]

vaccines...?

[E_L]

BioNTech is trying PD1-/PD-L1
Inhibitors with their mRNA Cancer vaccines in Melanoma; i wonder if this could be an area where the PD-L1x4-1BB duobody could be used instead?

[Sukkeralf]

I Guess so E L based on your comments from the transcript - lots of opportunities going forward with this program if the initial phase I/II data are good

[Sukkeralf]

And both Genmab and BioNTech seems quite thrilled so far - actualy it could be even a bigger product than Darzalex but thats years ahead from now and lots of hills or even mountains to climb

[nohope]

Has anybody ever gotten an approval for a mRNA vaccine ?

[E_L]

no, not yet

[nohope]

Well, I guess this what they call a really long shot in english.

[E_L]

sure. on the other hand, there has never been as much focus and as much research into mRNA as now, due to Covid, surely could lead to something

[nohope]

Yes, really comforting right ? The destiny of the world depends on a technique that has never had a positive outcome.

[E_L]

i am not so sure about that lol, many other trials going on. But , as they say, under pressure everything becomes fluid, let's 'hope' they are successful

[E_L]

the main focus for now for GEN1046
will be solid tumors anyway
.

[nohope]

The Manhattan project of our time ?

[E_L]

that was Daratumumab

[nohope]

A graphite moderated reactor a-la Tjernobyl - fired in the middle of a large town....

[nohope]

Noooo -Dara was done without time pressure - straight