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Genmab — December 2020

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
  • G Offline
    G Offline
    GeorgeBest
    wrote on sidst redigeret af
    #153

    Var det leukemi udover MM som de ville afprøve hexa-cd38 imod?

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    • BulderB Offline
      BulderB Offline
      Bulder
      wrote on sidst redigeret af
      #154

      Fra aftalen med Janssen: HexaBody-CD38 could be superior to daratumumab for certain tumor cell types and may expand and extend the promise of CD38-targeted therapies for more patients with multiple myeloma, lymphoma, leukemia, and potentially beyond.

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      • BulderB Offline
        BulderB Offline
        Bulder
        wrote on sidst redigeret af
        #155

        https://ir.genmab.com/news-releases/news-release-details/genmab-signs-agreement-janssen-next-generation-cd38-antibody/

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        • BulderB Offline
          BulderB Offline
          Bulder
          wrote on sidst redigeret af
          #156

          "beyond" kunne jo være solide?

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          • G Offline
            G Offline
            GeorgeBest
            wrote on sidst redigeret af
            #157

            Ja klart

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            • SolsenS Offline
              SolsenS Offline
              Solsen
              wrote on sidst redigeret af
              #158

              Hexa38 har præklinisk vist rigtig god effekt i DLBCL. Epco er også god her, men ellers en meget svær sygdom at kæmpe imod.

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              • E Offline
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                E_L
                wrote on sidst redigeret af
                #159

                https://twitter.com/HenrychihangFu1/status/1335039190845845504

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                • E Offline
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                  E_L
                  wrote on sidst redigeret af
                  #160

                  Dr Mark Wildgust: Updated APOLLO Trial Results Confirm Daratumumab Safety in Multiple Myeloma https://www.ajmc.com/view/dr-mark-wildgust-updated-apollo-trial-results-confirm-daratumumab-safety-in-multiple-myeloma - ONLY
                  5% of patients had infusion-related reactions in the APOLLO study, and all of those were grade 1/grade 2. So real confirmation that subcu dara is well tolerated.

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                  • E Offline
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                    E_L
                    wrote on sidst redigeret af
                    #161

                    https://genmab-at-ash-2020.com/ genmab-at-ash-2020

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                    • E Offline
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                      E_L
                      wrote on sidst redigeret af
                      #162

                      a bit strange when you look at the pipeline, poster on the right or https://virtualboothdemo.s3.amazonaws.com/Genmab/Content/PDFs/ash/I FINAL PIPELINE.pdf , it shows HexaBody CD38 in development phase I/II

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                      • BulderB Offline
                        BulderB Offline
                        Bulder
                        wrote on sidst redigeret af
                        #163

                        Must be because they plan to start one "soon".

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                        • BulderB Offline
                          BulderB Offline
                          Bulder
                          wrote on sidst redigeret af
                          #164

                          From August q&a: And are most excited and enthusiastic HexaBody-CD38 that is prepared for clinical
                          production in the coming months as well.

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                          • E Offline
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                            E_L
                            wrote on sidst redigeret af
                            #165

                            yes, i know it is supposed to come soon, i had hoped a bit just before ASH. But if it is not yet in the clinic, it is pre-clinical in my vocabulary 😉

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                              E_L
                              wrote on sidst redigeret af
                              #166

                              by the way, i also thought it was funny that Epco takes as much space on that page as Dara, Ofa and Tepezza together lol. How priorities
                              change

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                              • BulderB Offline
                                BulderB Offline
                                Bulder
                                wrote on sidst redigeret af
                                #167

                                Epco is the future. Tomorrow is as exciting as Sirius data in the past.

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                                • G Offline
                                  G Offline
                                  GeorgeBest
                                  wrote on sidst redigeret af
                                  #168

                                  Talquetamab https://twitter.com/mohty_ebmt/status/1335139956205948929?s=21

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                                  • E Offline
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                                    E_L
                                    wrote on sidst redigeret af
                                    #169

                                    yes, Sirius lol, that feels llike 100 years ago...

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                                    • BulderB Offline
                                      BulderB Offline
                                      Bulder
                                      wrote on sidst redigeret af
                                      #170

                                      It is. 33% ORR, and we all went berserk. Never seen before 🙂

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                                      • E Offline
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                                        E_L
                                        wrote on sidst redigeret af
                                        #171

                                        🙂 lets hope we have a simillar feeling this weekend

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                                        • E Offline
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                                          E_L
                                          wrote on sidst redigeret af
                                          #172

                                          this is where i think we will be able to see everything, Materials will be available on a rolling basis as soon as individual embargoes are lifted. Dara has some lifted already https://www.oncologysciencehub.com/ash2020/

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