Genmab — December 2020
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Sanofi kører et studie i Isatuximab + Cemiplimab mod bl.a. NSCLC. Winkel har tidligere sagt, at de vil afvente resultater fra dette studie, før der tages stilling til en evt. genoptagelse af daratumumab i solide.
https://www.clinicaltrials.gov/ct2/show/NCT03367819?term=isatuximab+solid+tumor&draw=2&rank=1 -
Jeg ved ikke om dette har været linket før https://clincancerres.aacrjournals.org/content/26/9/2203
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JNJ-7957 er det samme som teclistamab. peter's link er det prækliniske studie, som har ført videre til klinisk studie i dara+teclistamab i MM https://www.clinicaltrials.gov/ct2/show/NCT04108195?term=daratumumab+teclistamab&draw=2&rank=1
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Var det leukemi udover MM som de ville afprøve hexa-cd38 imod?
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Fra aftalen med Janssen: HexaBody-CD38 could be superior to daratumumab for certain tumor cell types and may expand and extend the promise of CD38-targeted therapies for more patients with multiple myeloma, lymphoma, leukemia, and potentially beyond.
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Ja klart
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Dr Mark Wildgust: Updated APOLLO Trial Results Confirm Daratumumab Safety in Multiple Myeloma https://www.ajmc.com/view/dr-mark-wildgust-updated-apollo-trial-results-confirm-daratumumab-safety-in-multiple-myeloma - ONLY
5% of patients had infusion-related reactions in the APOLLO study, and all of those were grade 1/grade 2. So real confirmation that subcu dara is well tolerated. -
https://genmab-at-ash-2020.com/ genmab-at-ash-2020
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a bit strange when you look at the pipeline, poster on the right or https://virtualboothdemo.s3.amazonaws.com/Genmab/Content/PDFs/ash/I FINAL PIPELINE.pdf , it shows HexaBody CD38 in development phase I/II
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