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Genmab — December 2020

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
  • BulderB Offline
    BulderB Offline
    Bulder
    wrote on sidst redigeret af
    #152

    Hvis Genmab/Janssen beslutter sig for at prøve igen med CD38 som mål for angreb på solide, bliver det nok ikke med dara men Hexabody cd38.

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    • G Offline
      G Offline
      GeorgeBest
      wrote on sidst redigeret af
      #153

      Var det leukemi udover MM som de ville afprøve hexa-cd38 imod?

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      • BulderB Offline
        BulderB Offline
        Bulder
        wrote on sidst redigeret af
        #154

        Fra aftalen med Janssen: HexaBody-CD38 could be superior to daratumumab for certain tumor cell types and may expand and extend the promise of CD38-targeted therapies for more patients with multiple myeloma, lymphoma, leukemia, and potentially beyond.

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        • BulderB Offline
          BulderB Offline
          Bulder
          wrote on sidst redigeret af
          #155

          https://ir.genmab.com/news-releases/news-release-details/genmab-signs-agreement-janssen-next-generation-cd38-antibody/

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          • BulderB Offline
            BulderB Offline
            Bulder
            wrote on sidst redigeret af
            #156

            "beyond" kunne jo være solide?

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            • G Offline
              G Offline
              GeorgeBest
              wrote on sidst redigeret af
              #157

              Ja klart

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              • SolsenS Offline
                SolsenS Offline
                Solsen
                wrote on sidst redigeret af
                #158

                Hexa38 har præklinisk vist rigtig god effekt i DLBCL. Epco er også god her, men ellers en meget svær sygdom at kæmpe imod.

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                • E Offline
                  E Offline
                  E_L
                  wrote on sidst redigeret af
                  #159

                  https://twitter.com/HenrychihangFu1/status/1335039190845845504

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                  • E Offline
                    E Offline
                    E_L
                    wrote on sidst redigeret af
                    #160

                    Dr Mark Wildgust: Updated APOLLO Trial Results Confirm Daratumumab Safety in Multiple Myeloma https://www.ajmc.com/view/dr-mark-wildgust-updated-apollo-trial-results-confirm-daratumumab-safety-in-multiple-myeloma - ONLY
                    5% of patients had infusion-related reactions in the APOLLO study, and all of those were grade 1/grade 2. So real confirmation that subcu dara is well tolerated.

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                    • E Offline
                      E Offline
                      E_L
                      wrote on sidst redigeret af
                      #161

                      https://genmab-at-ash-2020.com/ genmab-at-ash-2020

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                      • E Offline
                        E Offline
                        E_L
                        wrote on sidst redigeret af
                        #162

                        a bit strange when you look at the pipeline, poster on the right or https://virtualboothdemo.s3.amazonaws.com/Genmab/Content/PDFs/ash/I FINAL PIPELINE.pdf , it shows HexaBody CD38 in development phase I/II

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                        • BulderB Offline
                          BulderB Offline
                          Bulder
                          wrote on sidst redigeret af
                          #163

                          Must be because they plan to start one "soon".

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                          • BulderB Offline
                            BulderB Offline
                            Bulder
                            wrote on sidst redigeret af
                            #164

                            From August q&a: And are most excited and enthusiastic HexaBody-CD38 that is prepared for clinical
                            production in the coming months as well.

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                            • E Offline
                              E Offline
                              E_L
                              wrote on sidst redigeret af
                              #165

                              yes, i know it is supposed to come soon, i had hoped a bit just before ASH. But if it is not yet in the clinic, it is pre-clinical in my vocabulary 😉

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                              • E Offline
                                E Offline
                                E_L
                                wrote on sidst redigeret af
                                #166

                                by the way, i also thought it was funny that Epco takes as much space on that page as Dara, Ofa and Tepezza together lol. How priorities
                                change

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                                0
                                • BulderB Offline
                                  BulderB Offline
                                  Bulder
                                  wrote on sidst redigeret af
                                  #167

                                  Epco is the future. Tomorrow is as exciting as Sirius data in the past.

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                                  0
                                  • G Offline
                                    G Offline
                                    GeorgeBest
                                    wrote on sidst redigeret af
                                    #168

                                    Talquetamab https://twitter.com/mohty_ebmt/status/1335139956205948929?s=21

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                                    • E Offline
                                      E Offline
                                      E_L
                                      wrote on sidst redigeret af
                                      #169

                                      yes, Sirius lol, that feels llike 100 years ago...

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                                      • BulderB Offline
                                        BulderB Offline
                                        Bulder
                                        wrote on sidst redigeret af
                                        #170

                                        It is. 33% ORR, and we all went berserk. Never seen before 🙂

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                                        • E Offline
                                          E Offline
                                          E_L
                                          wrote on sidst redigeret af
                                          #171

                                          🙂 lets hope we have a simillar feeling this weekend

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