Genmab — September 2020

[Darvin]

Tillykke og godt gået Helge

[Darvin]

EL It was Rajkumar who announced It yesterday. And - depending on how you read the text - I read it as if they will open a trial for various autoimmune diseases - but only my way to read it

[E_L]

ok. we know Mayo has a Dara trial in CLL, in combination with Ibrutinib, will be interesting to see

[Bulder]

Could be RA. Has been discussed before. I think Janssen has an unused IND for dara in RA. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932888/

[E_L]

https://twitter.com/TiansterZhang/status/1308023977483227137 Amgen showing bispecific CD3x PSMA , like JNJ-63898081

[GeorgeBest]

Genmab and Seattle Genetics Present Data from Tisotumab Vedotin
innovaTV 204 Pivotal Trial in Recurrent or Metastatic Cervical Cancer at
ESMO Virtual Congress 2020

[GeorgeBest]

https://ir.genmab.com/news-releases/news-release-details/genmab-announces-janssen-has-submitted-supplemental-biologics

[GeorgeBest]

The results of the tisotumab vedotin phase 2 clinical trial are encouraging as they demonstrate clinically meaningful, durable responses with a manageable side effect profile

[E_L]

correction for the link GB https://ir.genmab.com/news-releases/news-release-details/genmab-and-seattle-genetics-present-data-tisotumab-vedotin

[GeorgeBest]

thanks E L

[Macabo]

ORR 24% og DOR 8,3 måneder - det er godt men ikke knock of socks niveau

[GeorgeBest]

der var ikke forventet mere for tiso

[bikube]

Det er da det man forstår ved "late breaking".

[Don_Joning]

nogen der har nogen bud på hvor værdifuldt tiso i cervical cancer kan blive?

[GeorgeBest]

knock your socks off data er mere relateret til epcoritamab og PD-L1x4-1BB

[GeorgeBest]

Tiso: jeg har set estimater på et topsalg på 750M USD i cervical cancer

[GeorgeBest]

årligt topsalg

[Don_Joning]

tak GB det er da alligevel også lidt...

[GeorgeBest]

skal også deles med SGEN

[Don_Joning]

ja, men er det ikke 50/50