Genmab — Juli 2018
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act, her udtager man også t-celler og fremstiller i laboratoriet en hybridform af to t-celle-undertyper - Th1 og Th17 - som kombinerer de cancerbekæmpende egnskaber ved Th1-cellerne med evnen hos Th17 til at forny sig selv og regenermere, og som sammen med et cd-38 antistof kan angribe tumorer mere effektivt.
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Immatics, som Genmab netop har indledt samarbejde med, har en del på bedding inden for ACT i samarbejde med MD Anderson. https://immatics.com/act.html
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Fin artikel om dara sc og amyloidosis (ANDROMEDA studiet) https://www.raredr.com/news/ray-comenzo-md-discusses-andromeda-trial-al-amyloidosis-patients
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"
The response rates were really stunning even though these patients in the ramp-in didn’t go through the entire course of therapy before the responses were scored. They are still getting treated, obviously, but three-quarters of patients recorded very deep responses" -
"If daratumumab and CyBorD works better than CyBorD alone, we have a new standard of therapy for patients with light chain amyloidosis. In addition, the study is designed to allow patients to have their blood stem cells collected after 6 months of treatment"
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Tak for link GB.
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den bed jeg også mærke i Helge 15.45 + "... 2 dozen patients were treated in the ramp-in, there was no safety problems with the subcutaneous daratumumab, and all of the 2 dozen patients received daratumumab with CyBorD.".
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5/7 15:46
af gentogen
It is estimated that there are 12,000 adults in the United States currently living with AL amyloidosis. (Blood Cancer Journalvolume 8, Article number: 44 (2018) -
har tidligere læst her at markedet for amyloidosis har en størrelses på ca. 20% af MM markedet
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noget kunne tyde på at dara virker endnu bedre i amyloisosis end i MM
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