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Genmab — Juni 2018

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
  • E Offline
    E Offline
    E_L
    wrote on sidst redigeret af
    #1861

    Nice article by Dr Plesner

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    • E Offline
      E Offline
      E_L
      wrote on sidst redigeret af
      #1862

      Daratumumab for the Treatment of Multiple Myeloma - https://www.frontiersin.org/articles/10.3389/fimmu.2018.01228/full

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      • E Offline
        E Offline
        E_L
        wrote on sidst redigeret af
        #1863

        "If further substantiated that an implication may be that daratumumab should be part of any anti-myeloma treatment. Given the pleiotropic effects of daratumumab, it is in fact difficult to imagine how a myeloma patient can become truly refractory to daratumumab."

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        • BulderB Offline
          BulderB Offline
          Bulder
          wrote on sidst redigeret af
          #1864

          Mere fra Journal of Immunology. 1. maj, 2018: Dara i CLL, http://www.jimmunol.org/content/200/1_Supplement/58.17

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          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #1865

            just enough reading material until 14.00 😉

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            • E Offline
              E Offline
              E_L
              wrote on sidst redigeret af
              #1866

              so @Bulder , that is the Mayo clinic looking to do that trial with CLL then I gues

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              • R Offline
                R Offline
                Raffles
                wrote on sidst redigeret af
                #1867

                Lad os håbe at JnJ snart får startet studier op med DARA i RA/SLE. Inden vi ser os om er det et år siden at JvdW nævnte at JnJ havde indsendt IND vedr DARA/RA!! Så det er på tide at komme videre:-)

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                • BulderB Offline
                  BulderB Offline
                  Bulder
                  wrote on sidst redigeret af
                  #1868

                  Yes, it looks like Mayo-people all over. Ohio State is currently running a combo with Ibrutinib https://www.clinicaltrials.gov/ct2/show/NCT03447808?term=daratumumab+cll&rank=1

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                  • BulderB Offline
                    BulderB Offline
                    Bulder
                    wrote on sidst redigeret af
                    #1869

                    If only we could get something cooking in RA and other blood cancers than MM, that could compensate for poor solid outcome.

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                    • I Offline
                      I Offline
                      Investor13
                      wrote on sidst redigeret af
                      #1870

                      Desværre fortsætter stigningen ikke i dag. TA mæssigt, er det vel vigtigt,
                      vi lukker over kurs 1000.

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                      • BulderB Offline
                        BulderB Offline
                        Bulder
                        wrote on sidst redigeret af
                        #1871

                        Der ligger iøvrigt også et potentiale for ofa i RA. GSK nåede faktisk at gennemføre et fase 1 med sc ofa i RA. Og iflg Winkel er Novartis bevidst om dette.

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                        • S Offline
                          S Offline
                          Sukkeralf
                          wrote on sidst redigeret af
                          #1872

                          Bulder selvfølgelig er Novartis bevidst om dette, når de har købt alle rettigheder - men tror det var sat igang, hvis man havde nogen interesse i det

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                          • SolsenS Offline
                            SolsenS Offline
                            Solsen
                            wrote on sidst redigeret af
                            #1873

                            GSK er et fyord på på linie med fabrik

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                            • S Offline
                              S Offline
                              Sukkeralf
                              wrote on sidst redigeret af
                              #1874

                              og dragen LD

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                              • M Offline
                                M Offline
                                mobbyduck1
                                wrote on sidst redigeret af
                                #1875

                                hehe

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                                • BulderB Offline
                                  BulderB Offline
                                  Bulder
                                  wrote on sidst redigeret af
                                  #1876

                                  Godt klar over at GSK er ugleset her på sitet. Men det var trods alt dem, der udviklede sc ofa. Der ligger 3 IV ofa i RA på CT, som blev afbrudt, fordi man ville gå over til sc. Og 1 gennemført sc i RA. Som herefter Novartis indtil videre har ignoreret.

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                                  • J Offline
                                    J Offline
                                    JKY_VH
                                    wrote on sidst redigeret af
                                    #1877

                                    Det var vel også der tilførte os 800 mio eller noget i den retning, da vi var ved at gå på r.... ?

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                                    • J Offline
                                      J Offline
                                      JKY_VH
                                      wrote on sidst redigeret af
                                      #1878

                                      dem

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                                      • royalR Offline
                                        royalR Offline
                                        royal
                                        wrote on sidst redigeret af
                                        #1879

                                        Hunden, ikke at forglemme. 🙂

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                                        • M Offline
                                          M Offline
                                          mobbyduck1
                                          wrote on sidst redigeret af
                                          #1880

                                          @Bulder, ja, men kan vi ikke også lige blive enige om, at GSK sparkede Ofa til hjørne, helt uden grund?? Meget godt move af Novartis vil jeg mene, tror bare de kun har fokus på MS

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