Genmab — April 2018

[Sukkeralf]

Måske også et lille slag i ansigtet til ADCT-301. For dem der følger Bergenbio så rart at det nye AXL ADCT-601 bruger den nye linker teknologi

[Sukkeralf]

Lidt fra Firstword: Final thoughts

Of course, one of the most high-profile reckonings for an ADC- and the PBD dimers used by ADC Therapeutics- will come from Stemcentrx and AbbVie's highly anticipated TRITON study of Rova-T. Unfortunately, AbbVie has already signalled that the outcome with be poor for the small-cell lung cancer candidate (SCLC);

[Sukkeralf]

last month it disclosed some mixed data and indicated it would not be pursuing accelerated approval for the compound. That said, companies like ADC Therapeutics can be confident that as long as the readout isn't dripping with safety concerns, their platform should still have legs

[Helge_LarsenPI-redaktør]

God morgen.

[polle1]

God morgen

[bibob]

God morgen :-).

[Parasitism]

God morgen

[rex_pacis]

God morgen

[JohnW]

God morgen Noget nyt om SH-tallene, eller er det blevet en non-event?

[Bulder]

Sukker, er det PDB'en eller er det linkeren, der er problemet?

[Bulder]

PBD

[Sukkeralf]

Det er nok mere komplekst end som så - tænker mest linkeren, men man skal nok grave lidt dybere i det. Som jeg husker det er PBD warheads ca. 1000 gange mere potent end eksempelvis MMAE, så det kræver jo at giften i endnu højere grad leveres det rette sted

[Bulder]

Av, det var voldsomt. Nu var lungeødem et af problemerne. Hvordan ser det ud med cd25 i lungerne - ved du det?

[Bulder]

Jeg kan se, Genmab skriver: limited expression on normal tissues

[Sukkeralf]

Det er vel noget i stil med dette Jan mener er problemet med CD38-ADC, at CD38 er udtrykt i lungerne

[Bulder]

Jeg har et spm til ham, om hvordan han ser på en dara adc sammen med actinium, som jo har haft et par fine abstracts på det seneste.

[Bulder]

... eller ARC, som det vist hedder, når det er noget radioaktivt, der kobles på mAb'en.

[E_L]

Fratricide of NK Cells in Daratumumab Therapy for Multiple Myeloma Overcome by Ex Vivo Expanded Autologous NK Cells
http://clincancerres.aacrjournals.org/content/early/2018/04/17/1078-0432.CCR-17-3117

[E_L]

are they now suggesting to take NK cells from daratumumab-treated patients, expand them in the lab, and infuse them into new patients before treatment with Dara?

[Bulder]

We discussed a similar issue 5. of March. The problem is that dara is killing NK-cells as they express cd38. Not good, as NK-cells were supposed til kill cancer. To overcome this problem it has been suggested to transplant fresh NK-cells from healthy donors. Now they suggest - as I understand it - to take NK-cells from
(other) dara-treated patients, as they mainly contain cd38-low NK-cells (the cd38-high NK-cells are depleted), and infuse them in patients.