Genmab — April 2018
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Lidt fra Firstword: Final thoughts
Of course, one of the most high-profile reckonings for an ADC- and the PBD dimers used by ADC Therapeutics- will come from Stemcentrx and AbbVie's highly anticipated TRITON study of Rova-T. Unfortunately, AbbVie has already signalled that the outcome with be poor for the small-cell lung cancer candidate (SCLC);
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last month it disclosed some mixed data and indicated it would not be pursuing accelerated approval for the compound. That said, companies like ADC Therapeutics can be confident that as long as the readout isn't dripping with safety concerns, their platform should still have legs
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God morgen.
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God morgen
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Det er nok mere komplekst end som så - tænker mest linkeren, men man skal nok grave lidt dybere i det. Som jeg husker det er PBD warheads ca. 1000 gange mere potent end eksempelvis MMAE, så det kræver jo at giften i endnu højere grad leveres det rette sted
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Fratricide of NK Cells in Daratumumab Therapy for Multiple Myeloma Overcome by Ex Vivo Expanded Autologous NK Cells
http://clincancerres.aacrjournals.org/content/early/2018/04/17/1078-0432.CCR-17-3117
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