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Genmab — April 2018

Planlagt Fastgjort Låst Flyttet Genmab
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  • Helge_LarsenPI-redaktørH Offline
    Helge_LarsenPI-redaktørH Offline
    Helge_LarsenPI-redaktør
    wrote on sidst redigeret af
    #1255

    Holdt foredrag i Svinningehallen her til aften. Genmab er stadig en folkeaktie. 🙂

    1 Reply Last reply
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    • M Offline
      M Offline
      Mayflower
      wrote on sidst redigeret af
      #1256

      Godmorgen 🙂

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      • S Offline
        S Offline
        Sukkeralf
        wrote on sidst redigeret af
        #1257

        Access denied | www.fiercebiotech.com used Cloudflare to restrict access | www.fiercebiotech.com | Cloudflare

        favicon

        (www.fiercebiotech.com)

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        • S Offline
          S Offline
          Sukkeralf
          wrote on sidst redigeret af
          #1258

          Måske også et lille slag i ansigtet til ADCT-301. For dem der følger Bergenbio så rart at det nye AXL ADCT-601 bruger den nye linker teknologi

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          • S Offline
            S Offline
            Sukkeralf
            wrote on sidst redigeret af
            #1259

            Lidt fra Firstword: Final thoughts

            Of course, one of the most high-profile reckonings for an ADC- and the PBD dimers used by ADC Therapeutics- will come from Stemcentrx and AbbVie's highly anticipated TRITON study of Rova-T. Unfortunately, AbbVie has already signalled that the outcome with be poor for the small-cell lung cancer candidate (SCLC);

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            • S Offline
              S Offline
              Sukkeralf
              wrote on sidst redigeret af
              #1260

              last month it disclosed some mixed data and indicated it would not be pursuing accelerated approval for the compound. That said, companies like ADC Therapeutics can be confident that as long as the readout isn't dripping with safety concerns, their platform should still have legs

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              • Helge_LarsenPI-redaktørH Offline
                Helge_LarsenPI-redaktørH Offline
                Helge_LarsenPI-redaktør
                wrote on sidst redigeret af
                #1261

                God morgen. 🙂

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                • P Offline
                  P Offline
                  polle1
                  wrote on sidst redigeret af
                  #1262

                  God morgen 🙂

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                  • B Offline
                    B Offline
                    bibob
                    wrote on sidst redigeret af
                    #1263

                    God morgen :-).

                    1 Reply Last reply
                    0
                    • P Offline
                      P Offline
                      Parasitism
                      wrote on sidst redigeret af
                      #1264

                      God morgen 🙂

                      1 Reply Last reply
                      0
                      • R Offline
                        R Offline
                        rex_pacis
                        wrote on sidst redigeret af
                        #1265

                        God morgen 🙂

                        1 Reply Last reply
                        0
                        • J Offline
                          J Offline
                          JohnW
                          wrote on sidst redigeret af
                          #1266

                          God morgen 🙂 Noget nyt om SH-tallene, eller er det blevet en non-event?

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                          0
                          • BulderB Offline
                            BulderB Offline
                            Bulder
                            wrote on sidst redigeret af
                            #1267

                            Sukker, er det PDB'en eller er det linkeren, der er problemet?

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                            • BulderB Offline
                              BulderB Offline
                              Bulder
                              wrote on sidst redigeret af
                              #1268

                              PBD

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                              • S Offline
                                S Offline
                                Sukkeralf
                                wrote on sidst redigeret af
                                #1269

                                Det er nok mere komplekst end som så - tænker mest linkeren, men man skal nok grave lidt dybere i det. Som jeg husker det er PBD warheads ca. 1000 gange mere potent end eksempelvis MMAE, så det kræver jo at giften i endnu højere grad leveres det rette sted

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                                • BulderB Offline
                                  BulderB Offline
                                  Bulder
                                  wrote on sidst redigeret af
                                  #1270

                                  Av, det var voldsomt. Nu var lungeødem et af problemerne. Hvordan ser det ud med cd25 i lungerne - ved du det?

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                                  0
                                  • BulderB Offline
                                    BulderB Offline
                                    Bulder
                                    wrote on sidst redigeret af
                                    #1271

                                    Jeg kan se, Genmab skriver: limited expression on normal tissues

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                                    0
                                    • S Offline
                                      S Offline
                                      Sukkeralf
                                      wrote on sidst redigeret af
                                      #1272

                                      Det er vel noget i stil med dette Jan mener er problemet med CD38-ADC, at CD38 er udtrykt i lungerne

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                                      • BulderB Offline
                                        BulderB Offline
                                        Bulder
                                        wrote on sidst redigeret af
                                        #1273

                                        Jeg har et spm til ham, om hvordan han ser på en dara adc sammen med actinium, som jo har haft et par fine abstracts på det seneste.

                                        1 Reply Last reply
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                                        • BulderB Offline
                                          BulderB Offline
                                          Bulder
                                          wrote on sidst redigeret af
                                          #1274

                                          ... eller ARC, som det vist hedder, når det er noget radioaktivt, der kobles på mAb'en.

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