Genmab — December 2016

[JKY_VH]

helt enig

[bibob]

Artikel på fierce biotech. - Loxo oncology. Loxo sets clock ticking on filing for first - in - class cancer drug. ( kan desværre ikke linke )

[JohnW]

Loxo oppe med 35% idag.

[E_L]

About the pan-Canadian Oncology Drug Review (pCODR)
Once Health Canada has approved a cancer drug for use in Canada, the
country's provinces and territories must decide if the drug will be eligible for public reimbursement. The CADTH pan-Canadian Oncology Drug Review (pCODR) plays an important role in their decision-making processes.

[E_L]

https://www.cadth.ca/darzalex-multiple-myeloma-details

[E_L]

Final Recommendation/Notification to implement
Issued for Daratumumab 16 Dec

[gentogen]

Det er jo helt oforståeligt

[gentogen]

Myeloma Canada submits that pERC failed to fully comprehend the gravity of this stage of disease in
patients. At this stage, patients have run out of options for treatment and are close to death. In
particular, the statement “there is a low probability that daratumumab would be cost-effective in this
population compared to other treatments” is at best conjectural and at worst insensitive.

[gentogen]

What other
“cost-effective” treatments is pERC recommending for this patient population? At the very least, a
recommendation should have been made for a sub-section of the indicated population.

[gentogen]

Myeloma Canada is of the opinion the pERC recommendations and comments are not supported by clinical
practices and are in fact contradictory to the evidence presented in the Clinical Guidance report.

[gentogen]

pERC also made some
assumptions that are not supported by either our patient survey or by the clinician survey, with respect to
the administration of daratumumab.

[gentogen]

Jeg kan desværre ikke kopiere fra selveafgørelsen men følg selv linket fra E L

[digafarm]

https://www.cadth.ca/sites/default/files/pcodr/pcodr_daratumumab_darzalex_mm_fn_rec.pdf

[digafarm]

En beslutning truffet 1/12 så vidt jeg kan se?

[Jedi]

Undskyld, men jeg kan kun finde Final Recommendation fra 1/12, men hvor ser I afgørelsen? (Som skulle være faldet 16/12)

[Jedi]

Eller der kommer måske bare ikke nogen notification ved negativ recommendation?

[Jedi]

En skandale for patienterne

[digafarm]

Tror d. 16. er implementeringsdatoen p.b.a. deres recommendation fra d. 1.

[digafarm]

Hvordan kan de komme frem til konklusionen om at darzalex ikke er kosteffektivt nok ift. andre behandlinger i min. 3. linje når det ikke har været et tema for FDA eller EM
A?

[Bulder]

Ja, det kan undre at de kan se så forskelligt på sagerne. Det hele er galt: for dyrt, for lidt effektivitet, for lang infusionstid, ingen bedre livskvalitet. Hvorfor har vi mon ikke hørt noget fra Janssen/Genmab? Kan de stadig være i dialog med de canadiske myndigheder?