Genmab — Maj 2014
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Sanofis kombo data med Revlimid er ikke mega stærke: The ORR (≥ PR), according to IMWG criteria, among 12 evaluable pts was 58 %. Responses occurred at each DL of 3mg/kg (1PR), 5mg/kg (1PR, 1 VGPR) and 10 mg/kg (1PR, 3 VGPR).
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pt. ingen CR !!!!!!!
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DARA+LEN+DEX has favorable safety profile with manageable toxicities in relapsed and RR MM. Encouraging early activity is seen with marked reduction in M-protein and 8/11 patients (72%) achieving PR or better. Part 2 data will be presented
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SAR overall response rate er ikke mega god. http://abstracts.asco.org/144/AbstView_144_129808.html kun 33% ORR i patienter behandlet med over 10 mg. de har dog 11% CR i de patienter. men stadigvæk.. Dara har noget højere ORR dog lavere CR
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http://abstracts.asco.org/144/AbstView_144_133856.html SAR ... Ja ikke skræmmende i konkurrencen
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OMFG tjek lige Ibrutinib+Arzerra kombi data. de er outstanding: Overall response rate in CLL/SLL was 100%
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http://abstracts.asco.org/144/AbstView_144_132436.html At study end, 52/58 responders (90%) remained progression-free with f/u of 16, 12 and 11 months for G1, 2 and 3, respectively
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det er i fuckin 72 patienter de leverer så høj en ORR
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det aller bedste er for mig at se at det ikke ser ud til at SAR er Dara overlegen.
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pt. vil jeg kalde dem equal
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deres follow up data viser kun 33% ORR i monoterapi. Daras viser 48%. De har så 11% CR hvor Dara ikke laver nogen
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i kombination med revlimid ser de også meget ens ud mht. effekt. osv. så first mover fordelen for Dara er virkelig en fordel
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og vildt med arzerra+ibrutinib kombi dataene. De må da tage det i phase III !!!!!!!!!
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jeg vil sige op pga. det giver mig en forløsning at dara ser ud til at være på niveau med SAR
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