Genmab — Maj 2014
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Sanofis kombo data med Revlimid er ikke mega stærke: The ORR (≥ PR), according to IMWG criteria, among 12 evaluable pts was 58 %. Responses occurred at each DL of 3mg/kg (1PR), 5mg/kg (1PR, 1 VGPR) and 10 mg/kg (1PR, 3 VGPR).
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pt. ingen CR !!!!!!!
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DARA+LEN+DEX has favorable safety profile with manageable toxicities in relapsed and RR MM. Encouraging early activity is seen with marked reduction in M-protein and 8/11 patients (72%) achieving PR or better. Part 2 data will be presented
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SAR overall response rate er ikke mega god. http://abstracts.asco.org/144/AbstView_144_129808.html kun 33% ORR i patienter behandlet med over 10 mg. de har dog 11% CR i de patienter. men stadigvæk.. Dara har noget højere ORR dog lavere CR
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http://abstracts.asco.org/144/AbstView_144_133856.html SAR ... Ja ikke skræmmende i konkurrencen
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OMFG tjek lige Ibrutinib+Arzerra kombi data. de er outstanding: Overall response rate in CLL/SLL was 100%
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http://abstracts.asco.org/144/AbstView_144_132436.html At study end, 52/58 responders (90%) remained progression-free with f/u of 16, 12 and 11 months for G1, 2 and 3, respectively
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det er i fuckin 72 patienter de leverer så høj en ORR
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det aller bedste er for mig at se at det ikke ser ud til at SAR er Dara overlegen.
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pt. vil jeg kalde dem equal
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deres follow up data viser kun 33% ORR i monoterapi. Daras viser 48%. De har så 11% CR hvor Dara ikke laver nogen
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i kombination med revlimid ser de også meget ens ud mht. effekt. osv. så first mover fordelen for Dara er virkelig en fordel
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og vildt med arzerra+ibrutinib kombi dataene. De må da tage det i phase III !!!!!!!!!
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jeg vil sige op pga. det giver mig en forløsning at dara ser ud til at være på niveau med SAR
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men ved ikke hvor meget frygt der er indregnet i markedet angående dette så kan ikke sige hvad kurspåvirkningen er. Men stærke data, men det er kun abstracts. Det er altid svært at læse noget ud fra abstracts. vi skal have de endelige posters til mødet, så er vi klogere om 14 dage
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