Anavex Ny tråd feb. 2023 - Nyt Parkinsonforsøg i Australien!
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Anavex PR på det nævnte patent af 2-73 + MJFF nyt.
ANAVEX Announces Issuance of New U.S. Intellectual Property Compositions Patent for ANAVEX®2-73 (blarcamesine)
NEW YORK, June 01, 2023 (GLOBE NEWSWIRE) -- Anavex Life Sciences Corp. (“Anavex” or the “Company”) (Nasdaq: AVXL), a clinical-stage biopharmaceutical company developing differentiated therapeutics for the treatment of neurodegenerative and neurodevelopmental disorders including Alzheimer’s disease, Parkinson’s disease, Rett syndrome and other central nervous system (CNS) disorders, announced today it was awarded new U.S. Patent No. 11,661,405 entitled “CRYSTAL FORMS OF TETRAHYDRO-N,N-DIMETHYL-2,
Yahoo Finance (finance.yahoo.com)
Juni 2023 update MJFF:
Neurorestorative Effects of a Sigma-1 Receptor Agonist in a Model of Parkinson’s Disease
Study Rationale: In a previous MJFF-sponsored project, we evaluated PRE-084 (an experimental compound binding to the sigma-1 receptor) in pre-clinical models of Parkinson’s disease. Chronic treatment with PRE-084 produced a gradual improvement of motor deficits and activated molecules involved in brain repair. In this project, we will evaluate a sigma-1 receptor agonist (ANAVEX2-73) produced by Anavex, which is now being evaluated in patients with Alzheimer’s disease. In our experimental study, the efficacy of ANAVEX2-73 on Parkinson’s biology will be compared to that of PRE-084 and other Sig-1R ligands.Hypothesis:The overarching aims of the study are to find a dose of ANAVEX2-73 producing a pattern of neurorestorative effects comparable to that of PRE-084 and to translate this dose into an equivalent dose for human use. Study Design:We will test the biological activity of ANAVEX2-73 in pre-clinical models and compare to PRE-084, previously shown to promote recovery of forelimb use, up-regulation of trophic factors and anti-inflammatory effects in the brain in this model. We will assess target engagement by measuring the ability of the tested compounds to prevent a radioactive ligand from binding to brain sigma-1 receptors. Impact on Diagnosis/Treatment of Parkinson’s Disease: The present study holds potential to impact the way Parkinson’s disease is treated. We aim to develop a new pharmacological approach to boost repair mechanisms and dampen inflammation in the part of the brain that is most affected by Parkinson’s. If this treatment exerts the expected effects, it could slow the progression of the disease. Next Steps for Development:If successful, this study will accelerate the translation of pre-clinical findings into the first clinical trial of ANAVEX2-73 as a potential disease-modifying therapy for Parkinson’s disease. ANAVEX2-73 has already been tested for safety and tolerability in humans with positive results.
The Michael J. Fox Foundation for Parkinson's Research | Parkinson's Disease (www.michaeljfox.org)
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Anavex Ja kan godt se nu, at der ingen dato er på MJFF - det er de faktisk rigtig dårlige til at angive - så dette kan meget vel være af ældre dato?
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Anavex. BP har 1400 - 1500 milliarder $ til bl.a. opkøb!
Patentudløb truer flere BP`er - løsningen er iflg. artiklen opkøb af biotekselskaber med en lovende pipeline - og især af den type, som Anavex repræsenterer med oral og lille molekylestruktur.
BP har tjent styrtende under bl.a. Corona og man har set et stigende antal opkøb ifht. tidligere år.
Iflg Missling var der stor interesse for partneraftaler med Anavex, men når BP nu har pengepungen helt fyldt op til bristepunktet, så ville de nok helst bare købe Anavex - hvis data i AD og måske også RETT er så overbevisende, som jeg mener er stillet os i udsigt.
Så med gode data, kan tingene gå rigtig hurtigt - er overbevist om, at Anavex er langt henne i evt. udformning af partneraftaler - dog betinget af at skidtet virker!- Selvom "hurtigt" normalt ikke er et udtryk vi kan forbinde med Anavex:)
"With patent cliffs and Medicare pricing in mind, "What would the rational economic actor do?" asked Greg Grove, an attorney with the law firm Neal Gerber Eisenberg. Grove assists life sciences companies with transactions.
The clear answer, experts say, is to buy promising new drugs or companies."
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UBS har øget deres andel i Anavex ifølge denne:
Stock Market Alerts | MarketBeat
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(www.marketbeat.com)
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Anavex Vi kan nok forvente TLD for Excellence okt. 2023.
Anavex kunne godt have oplyst, hvor mange af de 92 piger, der ønsker at forsætte i OLE forsøget.
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The Company expects to announce topline results from this study in the second half of this year.
Eller næste år eller der omkring -
Rimeligt lille forsøg så de burde have TLD klar til sep/okt, isaer med 3 tidligere FDA folk i firmaet.
Ak ja så er der sgu snart gået et år mere.Gider ikke at læse indlæg på Ihub mere omkring AVXL medmindre jeg ser noget nyt på Yahoo finance.
Det er en stor børnehave, men kan dog til tider værre hylende morsomme at læse hvis jeg keder mig. -
Annovis Bio (ANVS) spilder ikke tiden (host-host) men har indrullet 520 patienter på bare 9 måneder i deres fase3 (ja fase 3 og ikke 2/3- host host) i Parkinson's.
De er en direkte konkurent til Anavex og har også AD forsøg men tror at Anavex har den bedste medicin. -
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Udløb på call optioner kan være årsag.
https://finance.yahoo.com/quote/AVXL/options?date=1686268800&p=AVXL -
Breaking
An FDA advisory panel has voted 6-0 in favour of recommending that Eisai and Biogen's Alzheimer's drug Leqembi be granted full approval. -
Anavex Life Sciences Reports Publication in Medical Journal Signifying Continued Commitment for Improvement of the Rett Syndrome Caregiver Outcome Measure RSBQ
NEW YORK, June 12, 2023 (GLOBE NEWSWIRE) -- Anavex Life Sciences Corp. (“Anavex” or the “Company”) (Nasdaq: AVXL), a clinical-stage biopharmaceutical company developing differentiated therapeutics for the treatment of neurodegenerative and neurodevelopmental disorders including Alzheimer’s disease, Parkinson’s disease, Rett syndrome and other central nervous system (CNS) disorders, today announced the publication of a relevant new peer-reviewed study in the American Journal on Intellectual and D
Yahoo Finance (finance.yahoo.com)
NEW YORK, June 12, 2023 (GLOBE NEWSWIRE) -- Anavex Life Sciences Corp. ("Anavex" or the "Company") (Nasdaq: AVXL), a clinical-stage biopharmaceutical company d...
Lidt fremgang er der da.
ja hvis det ikke bliver i 25 eller 26 eller....
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