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  4. Genmab — Marts 2025

Genmab — Marts 2025

Planlagt Fastgjort Låst Flyttet Genmab
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  • SolsenS Offline
    SolsenS Offline
    Solsen
    wrote on sidst redigeret af
    #842

    Correct DAR8 - Rina-S is an ADC comprised of a folate receptor-alpha-directed antibody conjugated to sesutecan, ProfoundBio’s novel, proprietary hydrophilic exatecan-based linker-drug, LD038, at a homogeneous drug-to-antibody ratio (DAR) of 8. Exatecan is a highly potent, membrane permeable topoisomerase-1 inhibitor with strong bystander effect that has been extensively studied as a small molecule anticancer agent. Sesutecan is a highly hydrophilic stable, cleavable linker designed to mask the

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    • SolsenS Offline
      SolsenS Offline
      Solsen
      wrote on sidst redigeret af
      #843

      hydrophobicity of conjugated exatecan on the ADC, enabling high DAR and efficient delivery of the exatecan payload to tumors while maintaining favorable physicochemical and pharmacokinetic properties of the ADC.

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      • G Offline
        G Offline
        gentogen
        wrote on sidst redigeret af
        #844

        Ifølge det tidligere link til omtalen af Abbvies sagsanlæg, så er det sådan, at "ProfoundBio began filing patents and promoting its linker technology in 2021," Så de kunne have anfægtet patentet i flere år

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        • G Offline
          G Offline
          gentogen
          wrote on sidst redigeret af
          #845

          Den anklagede person er endda officiel medopfinder af ProfoundBios patent, så vedkommende har da ikke skjult sin relation til ProfoundBio, så igen: Abbvie har haft fere år, hvor de kunne have anfægtet patentet

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          • G Offline
            G Offline
            gentogen
            wrote on sidst redigeret af
            #846

            Link Preview Image
            US20240207429A1 - Linkers, drug linkers and conjugates thereof and methods of using the same - Google Patents

            The present invention provides Polar units, Linker intermediates, Linkers, Drug-Linkers and Conjugates thereof.

            favicon

            (patents.google.com)

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            • E Offline
              E Offline
              E_L
              wrote on sidst redigeret af
              #847

              Rova-T: the story of AbbVie’s multi-billion dollar failure -I'll have another look at this story tomorrow, but maybe this is also about AbbVie having a grudge with former Stemcentrx employees... https://www.science.org/content/blog-post/last-stemcentrx

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              • L Offline
                L Offline
                lahn1
                wrote on sidst redigeret af
                #848

                Everyone won big time on Stemcentrx except Abbvie. Is IMGN just another failure in the line af disasters by Abbvie ?

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                • L Offline
                  L Offline
                  lahn1
                  wrote on sidst redigeret af
                  #849

                  Founder of Profound come from Stemcentrx got hired at Abbvie and left and then developed Rina-s which is better tha Elahere double whammy 😄

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                  • R Offline
                    R Offline
                    Raun
                    wrote on sidst redigeret af
                    #850

                    😄

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                    • SolsenS Offline
                      SolsenS Offline
                      Solsen
                      wrote on sidst redigeret af
                      #851

                      What a story 🙂

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                      • L Offline
                        L Offline
                        lahn1
                        wrote on sidst redigeret af
                        #852

                        Abbvie tabte en meget ligende sag mod Adcentrx. Dommeren afviste sagen grundet manglende beviser på en kriminel handling. https://casetext.com/case/abbvie-inc-v-adcentrx-therapeutics-inc?utm_source=chatgpt.com&__cf_chl_rt_tk=6cLBbJCdxo3.l47PVnxvbN5nCD55gIk5u605i6EDfmg-1742847322-1.0.1.1-dnnmMeqSOFS.oHThbMIG.pnL8_CO9u_dEtkfHwXHyc8

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                        • T Offline
                          T Offline
                          transalp
                          wrote on sidst redigeret af
                          #853

                          Go morgen.. 🙂

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                          • E Offline
                            E Offline
                            E_L
                            wrote on sidst redigeret af
                            #854

                            Store fremskridt i behandling af knoglemarvskræft https://www.myelomatose.dk/nyheder/store-fremskridt-i-behandling-af-knoglemarvskraeft/

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                            • E Offline
                              E Offline
                              E_L
                              wrote on sidst redigeret af
                              #855

                              Bolt Biotherapeutics Reports Full-Year 2024 Financial Results https://investors.boltbio.com/news-releases/news-release-details/bolt-biotherapeutics-reports-fourth-quarter-and-full-year-2024 - The Company continues to work with Genmab to discover and develop next-generation ISACs for the treatment of cancer. Genmab and the Company are working together to advance the collaboration’s first development candidate, and the collaboration also continues research and development on additional programs.

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                              • E Offline
                                E Offline
                                E_L
                                wrote on sidst redigeret af
                                #856

                                Bolt Presentation
                                https://investors.boltbio.com/static-files/397f2c02-b515-44a2-a108-6e1302a91a98

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                                0
                                • E Offline
                                  E Offline
                                  E_L
                                  wrote on sidst redigeret af
                                  #857

                                  AbbVie and Genmab: Can a legal battle break a billion-dollar bond? https://www.labiotech.eu/trends-news/abbvie-genmab-lawsuit/

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                                  • SEACOPS Offline
                                    SEACOPS Offline
                                    SEACOP
                                    wrote on sidst redigeret af
                                    #858

                                    Lahn 22:36: Dommerens afvisning 7½ mdr. (15.12.2023 - 29:07.2024).

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                                    • E Offline
                                      E Offline
                                      E_L
                                      wrote on sidst redigeret af
                                      #859

                                      Novartis to present new data at AAN, including seven-year disability outcomes and safety analysis of Kesimpta® in people with relapsing multiple sclerosis
                                      Mar 25, 2025 https://www.novartis.com/news/media-releases/novartis-present-new-data-aan-including-seven-year-disability-outcomes-and-safety-analysis-kesimpta-people-relapsing-multiple-sclerosis

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                                      • E Offline
                                        E Offline
                                        E_L
                                        wrote on sidst redigeret af
                                        #860

                                        Rina-S Elicited Responses With/Without FRα Expression in Ovarian Cancer https://www.cancernetwork.com/view/rina-s-elicited-responses-with-without-fr-expression-in-ovarian-cancer

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                                        • Helge_LarsenPI-redaktørH Offline
                                          Helge_LarsenPI-redaktørH Offline
                                          Helge_LarsenPI-redaktør
                                          wrote on sidst redigeret af
                                          #861

                                          E L, thank you very much for the link10.08. The article provides relevant perspective on AbbVie's lawsuit against Genmab.

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                                          0

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