Genmab — Marts 2025
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Abbvies opfølger IMGN151 er i fase 1 siden december 2022 og har en DAR på 3,5 med deres payload DM21 https://aacrjournals.org/cancerres/article/80/16_Supplement/2890/642251/Abstract-2890-IMGN151-A-next-generation-folate Rina-S har DAR 6 med topoisomerase 1 inhibitor som payload. Hvilket stof der er bedst må tiden vise. Jeg har ikke fundet data på patienter fra IMGN151.
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Correct DAR8 - Rina-S is an ADC comprised of a folate receptor-alpha-directed antibody conjugated to sesutecan, ProfoundBio’s novel, proprietary hydrophilic exatecan-based linker-drug, LD038, at a homogeneous drug-to-antibody ratio (DAR) of 8. Exatecan is a highly potent, membrane permeable topoisomerase-1 inhibitor with strong bystander effect that has been extensively studied as a small molecule anticancer agent. Sesutecan is a highly hydrophilic stable, cleavable linker designed to mask the
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US20240207429A1 - Linkers, drug linkers and conjugates thereof and methods of using the same - Google Patents
The present invention provides Polar units, Linker intermediates, Linkers, Drug-Linkers and Conjugates thereof.
(patents.google.com)
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Rova-T: the story of AbbVie’s multi-billion dollar failure -I'll have another look at this story tomorrow, but maybe this is also about AbbVie having a grudge with former Stemcentrx employees... https://www.science.org/content/blog-post/last-stemcentrx
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Abbvie tabte en meget ligende sag mod Adcentrx. Dommeren afviste sagen grundet manglende beviser på en kriminel handling. https://casetext.com/case/abbvie-inc-v-adcentrx-therapeutics-inc?utm_source=chatgpt.com&__cf_chl_rt_tk=6cLBbJCdxo3.l47PVnxvbN5nCD55gIk5u605i6EDfmg-1742847322-1.0.1.1-dnnmMeqSOFS.oHThbMIG.pnL8_CO9u_dEtkfHwXHyc8
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Store fremskridt i behandling af knoglemarvskræft https://www.myelomatose.dk/nyheder/store-fremskridt-i-behandling-af-knoglemarvskraeft/
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Bolt Biotherapeutics Reports Full-Year 2024 Financial Results https://investors.boltbio.com/news-releases/news-release-details/bolt-biotherapeutics-reports-fourth-quarter-and-full-year-2024 - The Company continues to work with Genmab to discover and develop next-generation ISACs for the treatment of cancer. Genmab and the Company are working together to advance the collaboration’s first development candidate, and the collaboration also continues research and development on additional programs.
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