Genmab — Marts 2025
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Correct DAR8 - Rina-S is an ADC comprised of a folate receptor-alpha-directed antibody conjugated to sesutecan, ProfoundBio’s novel, proprietary hydrophilic exatecan-based linker-drug, LD038, at a homogeneous drug-to-antibody ratio (DAR) of 8. Exatecan is a highly potent, membrane permeable topoisomerase-1 inhibitor with strong bystander effect that has been extensively studied as a small molecule anticancer agent. Sesutecan is a highly hydrophilic stable, cleavable linker designed to mask the
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US20240207429A1 - Linkers, drug linkers and conjugates thereof and methods of using the same - Google Patents
The present invention provides Polar units, Linker intermediates, Linkers, Drug-Linkers and Conjugates thereof.
(patents.google.com)
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Rova-T: the story of AbbVie’s multi-billion dollar failure -I'll have another look at this story tomorrow, but maybe this is also about AbbVie having a grudge with former Stemcentrx employees... https://www.science.org/content/blog-post/last-stemcentrx
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Abbvie tabte en meget ligende sag mod Adcentrx. Dommeren afviste sagen grundet manglende beviser på en kriminel handling. https://casetext.com/case/abbvie-inc-v-adcentrx-therapeutics-inc?utm_source=chatgpt.com&__cf_chl_rt_tk=6cLBbJCdxo3.l47PVnxvbN5nCD55gIk5u605i6EDfmg-1742847322-1.0.1.1-dnnmMeqSOFS.oHThbMIG.pnL8_CO9u_dEtkfHwXHyc8
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Store fremskridt i behandling af knoglemarvskræft https://www.myelomatose.dk/nyheder/store-fremskridt-i-behandling-af-knoglemarvskraeft/
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Bolt Biotherapeutics Reports Full-Year 2024 Financial Results https://investors.boltbio.com/news-releases/news-release-details/bolt-biotherapeutics-reports-fourth-quarter-and-full-year-2024 - The Company continues to work with Genmab to discover and develop next-generation ISACs for the treatment of cancer. Genmab and the Company are working together to advance the collaboration’s first development candidate, and the collaboration also continues research and development on additional programs.
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AbbVie and Genmab: Can a legal battle break a billion-dollar bond? https://www.labiotech.eu/trends-news/abbvie-genmab-lawsuit/
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Novartis to present new data at AAN, including seven-year disability outcomes and safety analysis of Kesimpta
in people with relapsing multiple sclerosis
Mar 25, 2025 https://www.novartis.com/news/media-releases/novartis-present-new-data-aan-including-seven-year-disability-outcomes-and-safety-analysis-kesimpta-people-relapsing-multiple-sclerosis
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