Genmab — Februar 2025
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Darvin - meget interessant vinkel den med Fastpro er et nyt drug. Er der en kattelem i Erzo kontrakten der beskytter Dara mod konkurrence og ikke specifikt beskytter mod konkurrence i MM indikationen. Ville være fedt med payback til JnJ hvis det var casen
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Should Janssen not exercise its option, the terms of the agreement allow Genmab to continue to develop and commercialize HexaBody-CD38 for DARZALEX-resistant patients, and in all other
indications except those multiple myeloma or amyloidosis indications where DARZALEX is either approved or is being actively developed. -
@lahn1 Genmab kan i MM
kun markedsføre Erzo I Dara resistente patienter. Som vist ikke er et ret stort marked. -
Ikke sikker på det er så simpelt desværre - gætter på at der i forbindelse med licensaftalen på daratumumab er forlangt af Janssen at GEnmab ikke må arbejde mere indenfor CD38, så længe aftalen løber. Genmab har så henvendt sig til Janssen med muligheden for HexaCD38 og de har indgået en aftale om at Genmab må arbejde i området mod at Janssen får optionen. Så noget for noget deal. Genmab må muligvis begynde arbejde indenfor CD38 efter 2030, men så tager det jo en del tid at nå over målstregen.
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from last summer; Daratumumab Retreatment Leads to Responses in Relapsed/Refractory Myeloma https://www.onclive.com/view/daratumumab-retreatment-leads-to-responses-in-relapsed-refractory-myeloma "generated a similar overall response rate compared with initial treatment with a daratumumab-based regimen "
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EL, that is super interesting. But Jan did not sound like he thinks there will be a market for Erzo at the earnings cal when asked what if ... would Gmab develop Erzo further. Oddly if he thinks the Erzo is such a good drug. But I think I would prefer Gmab hold on to Erzo rather than make a new Erzo agreement with JnJ for alle indications with a low single digit royalty.
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“I think the data looks brilliant. I mean, where you would have told me 10 years ago that it is possible to make a more positive antibody than daratumumab, I would have laughed at it because I wouldn't have believed it because daratumumab is a unique antibody, is one of the best therapeutic antibodies developed over the last decades.
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