Genmab — September 2020
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En fin analyse i øvrigt, af David Mygind. https://ugebrev.dk/life-science/her-er-indholdet-i-seneste-oeu-life-science-med-bl-a-genmab/
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God morgen.
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kkjoel. Enig. David er stærk på Genmab.
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JNJ progressing Teclistamab into a PhII trial https://clinicaltrials.gov/ct2/show/NCT04557098?term=Teclistamab&draw=2&rank=1
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Combo of ADC Amivantamab & Lazertinib looks good for Osi resistant #EGFR+ #lungcancer. 36% ORR & 100% in treatment naive pts! Questions remain about mech of resistance & use of 1st line BUT as patient I’m a bit concerned about toxicities! https://twitter.com/jillfeldman4/status/1307671624435589120?s=21
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CHRYSALIS Amivantamab + lazeritinib. Looks a bit toxic to me. Active is Osimertinib resistance. 100% RR in treatment naive! https://twitter.com/drriyazshah/status/1307662972429500418?s=21
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MET inhibition + double EGFR inhibition is a win.
Amivantamab (bispecific EGFR/MET Ab)+ Lazertinib (3rd gen TKI) rescue osimertinib resistant pts with EGFRmut NSCLC: ORR 36%.
Will be compared to osi 1st line in a Phase III trial.
Dual EGFR/MET tox to be followed... https://twitter.com/benjaminbessemd/status/1307672214972641280?s=21 -
Nice data for$JNJ amivantamab and lazertinib - looks good for post $AZN @TAGRISSO_AZ and also for treatment naïve patients. JNJ certainly has the hope of beating Tagrisso with a head to head phase III. https://twitter.com/samfazeli8/status/1307663441210019840?s=21
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#Amivantanab in Combination with Lazertinib
Exciting data in Osimertinib-resistan pts
ORR 36%
6% of discontinuation due AEsExcellent data for the EGFR community https://twitter.com/apassaromd/status/1307663461070106626?s=21
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Janssen Presents Findings from Global, Multi-Center Trial Examining Amivantamab in Combination with Lazertinib in Patients with EGFR-Mutated Non-Small Cell Lung Cancer https://www.prnewswire.com/news-releases/janssen-presents-findings-from-global-multi-center-trial-examining-amivantamab-in-combination-with-lazertinib-in-patients-with-egfr-mutated-non-small-cell-lung-cancer-301134336.html
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Kan kke huske om dette fra bl.a. Ola Landgren har været nævnt: Ola Landgren, M.D.:
Evidence of strong clinical benefit when using CD38 targeted monoclonal antibody (daratumumab) in two patients with refractory, life-threatening Systemic Lupus Erythematosus (SLE). May become an important treatment strategy for many autoimmune diseases in the future? -
God morgen.
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