Genmab — September 2020

[kkjoel]

Ved ikke om han har været ude - men anbefalingen blev i al fald hævet til køb fra neutral. Han kunne jo osse bare have været neutral! (~ inde, men uden at øge andelen?)

[nohope]

Ok.

[GeorgeBest]

Combo of ADC Amivantamab & Lazertinib looks good for Osi resistant #EGFR+ #lungcancer. 36% ORR & 100% in treatment naive pts! Questions remain about mech of resistance & use of 1st line BUT as patient I’m a bit concerned about toxicities! https://twitter.com/jillfeldman4/status/1307671624435589120?s=21

[GeorgeBest]

CHRYSALIS Amivantamab + lazeritinib. Looks a bit toxic to me. Active is Osimertinib resistance. 100% RR in treatment naive! https://twitter.com/drriyazshah/status/1307662972429500418?s=21

[GeorgeBest]

MET inhibition + double EGFR inhibition is a win.
Amivantamab (bispecific EGFR/MET Ab)+ Lazertinib (3rd gen TKI) rescue osimertinib resistant pts with EGFRmut NSCLC: ORR 36%.
Will be compared to osi 1st line in a Phase III trial.
Dual EGFR/MET tox to be followed... https://twitter.com/benjaminbessemd/status/1307672214972641280?s=21

[GeorgeBest]

Nice data for$JNJ amivantamab and lazertinib - looks good for post $AZN @TAGRISSO_AZ and also for treatment naïve patients. JNJ certainly has the hope of beating Tagrisso with a head to head phase III. https://twitter.com/samfazeli8/status/1307663441210019840?s=21

[GeorgeBest]

#Amivantanab in Combination with Lazertinib
Exciting data in Osimertinib-resistan pts
ORR 36%
6% of discontinuation due AEs

Excellent data for the EGFR community https://twitter.com/apassaromd/status/1307663461070106626?s=21

[E_L]

@kkjoel IF so, we should find out soon; Amivantamab is also already starting 2 Ph II trials

[E_L]

Janssen Presents Findings from Global, Multi-Center Trial Examining Amivantamab in Combination with Lazertinib in Patients with EGFR-Mutated Non-Small Cell Lung Cancer https://www.prnewswire.com/news-releases/janssen-presents-findings-from-global-multi-center-trial-examining-amivantamab-in-combination-with-lazertinib-in-patients-with-egfr-mutated-non-small-cell-lung-cancer-301134336.html

[peter12]

Lidt fra fierce https://www.fiercebiotech.com/biotech/esmo-janssen-s-anti-egfr-combo-tackles-lung-cancer-ahead-phase-3-tagrisso-showdown

[Darvin]

Kan kke huske om dette fra bl.a. Ola Landgren har været nævnt: Ola Landgren, M.D.:
Evidence of strong clinical benefit when using CD38 targeted monoclonal antibody (daratumumab) in two patients with refractory, life-threatening Systemic Lupus Erythematosus (SLE). May become an important treatment strategy for many autoimmune diseases in the future?

[Darvin]

Mere - det er det jo nok - og sikker også at MayoClinic starter trial på området

[Helge_LarsenPI-redaktør]

God morgen.

[Helge_LarsenPI-redaktør]

Servicemeddelelse: Jeg har de seneste uger tegnet nye partneraftaler og et større antal annoncer for det kommende år. Dermed bliver det ikke nødvendigt med donationer længere. På et et tidspunkt vil jeg muligvis indføre et frivilligt support-abonnement til en fast lav pris. Tak for jeres støtte. Uden den - intet PI.

[GeorgeBest]

Tillykke Helge

[transalp]

Go morgen.. godt at høre det lysner for PI . Tak i lige måde .

[bibob]

Onc.live : Amivantamab https://www.onclive.com/view/egfr-met-bispecific-antibody-amivantamab-excels-in-advanced-egfr-mutant-nsclc?eKey=amFuYm9ydXAxOTc4QGdtYWlsLmNvbQ==

[E_L]

2 more twitter threads on Amivantamab, Stephen V Liu https://twitter.com/StephenVLiu/status/1307692420528832513 and Joshua Bauml https://twitter.com/Jbauml/status/1307839573435781120

[E_L]

and since nobody bothered to correct my comment from yesterday evening (even thought i am sure you had all seen the mistake) ; i meant 2 Ph III trials for Amivantamab

[E_L]

@Darvin for Mayo to start a trial is definately news. Really curious if it will be only for Lupus or also for other autoimmune diseases? The NEJM article attracted a surprisingly large number of positive comments from MDs on twitter over the last few days.