Genmab — August 2020

[Sukkeralf]

Characterization of concurrent target suppression by JNJ-61178104, a bispecific antibody against human tumor necrosis factor and interleukin-17A - PubMed

Tumor necrosis factor (TNF) and interleukin (IL)-17A are pleiotropic cytokines implicated in the pathogenesis of several autoimmune diseases including rheumatoid arthritis (RA) and psoriatic arthritis (PsA). JNJ-61178104 is a novel human anti-TNF and anti-IL-17A monovalent, bispecific antibody that …

PubMed (pubmed.ncbi.nlm.nih.gov)

[Sukkeralf]

JNJ-61178104 was shown to engage its targets, TNF and IL-17A, in systemic circulation measured as drug/target complex formation in normal cynomolgus monkeys (cyno). Surprisingly, quantitative target engagement assessment suggested lower apparent in vivo target-binding affinities for JNJ-61178104 compared to its bivalent parental antibodies, despite their similar in vitro target-binding affinities.

[Sukkeralf]

The target engagement profiles of JNJ-61178104 in humans were in general agreement with the predicted profiles based on cyno data, suggesting similar differences in the apparent in vivo target-binding affinities. These findings show that in vivo target engagement of monovalent bispecific antibody does not necessarily recapitulate that of the molar-equivalent dose of its bivalent parental antibody

[Sukkeralf]

Our results also offer valuable insights into the understanding of the pharmacokinetics/pharmacodynamics and target engagement of other bispecific biologics against dimeric and/or trimeric soluble targets in vivo.

[E_L]

it is a shame as it is the only JNJ non-cancer duobody as far as i am aware of? i am not sure how much 'valuable insights' they gained from this, besides confirming how hard it is lol

[E_L]

but , who knows, maybe in 20 years or so they will find it actually works for Graves disease or something

[E_L]

actually only just noticed that clicking on the link behing DOI will give the full article,

[Sukkeralf]

I dont spend time reading that stuff - do you ?

[E_L]

as far as i think it could be usefull, i do, depends a bit on how technical it is, i never studied biochemistry.... but here for example only reading 'discussion' is insightfull, it elaborates a bit on what you posted

[Sukkeralf]

yes that also what i goes after - "results", "discussion" or "conclusion" just to get the essence of the article

[Sukkeralf]

Skal vi mon lukke over 2300 i dag

[Vitus]

Mon dog....

[Vitus]

Tegner ikke for godt nu...

[AaBforever]

Hvornår mon starter fyrværkeriet...stilheden før stormen?

[AaBforever]

Efter onsdag..måske. Der er ikke så mange ønsker om gode fredags nyheder som i "gamle" dage.

[Legolas23]

Sikke en teaser - 2299

[AaBforever]

Nemlig lego...mere kul på..:-D

[Vitus]

Okay.... vi må prøve at leve med det

[Helge_LarsenPI-redaktør]

Jeg har slettet reklamen for mine mundbind i denne tråd. jeg lægger en regulær bannerannonce op med PI rabat senere i dag eller i morgen.

[Solsen]

Super