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Genmab — August 2020

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
  • S Offline
    S Offline
    Sukkeralf
    wrote on sidst redigeret af
    #115

    The target engagement profiles of JNJ-61178104 in humans were in general agreement with the predicted profiles based on cyno data, suggesting similar differences in the apparent in vivo target-binding affinities. These findings show that in vivo target engagement of monovalent bispecific antibody does not necessarily recapitulate that of the molar-equivalent dose of its bivalent parental antibody

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    • S Offline
      S Offline
      Sukkeralf
      wrote on sidst redigeret af
      #116

      Our results also offer valuable insights into the understanding of the pharmacokinetics/pharmacodynamics and target engagement of other bispecific biologics against dimeric and/or trimeric soluble targets in vivo.

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      • E Offline
        E Offline
        E_L
        wrote on sidst redigeret af
        #117

        it is a shame as it is the only JNJ non-cancer duobody as far as i am aware of? i am not sure how much 'valuable insights' they gained from this, besides confirming how hard it is lol

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        • E Offline
          E Offline
          E_L
          wrote on sidst redigeret af
          #118

          but , who knows, maybe in 20 years or so they will find it actually works for Graves disease or something 😉

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          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #119

            actually only just noticed that clicking on the link behing DOI will give the full article,

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            • S Offline
              S Offline
              Sukkeralf
              wrote on sidst redigeret af
              #120

              I dont spend time reading that stuff - do you ?

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              • E Offline
                E Offline
                E_L
                wrote on sidst redigeret af
                #121

                as far as i think it could be usefull, i do, depends a bit on how technical it is, i never studied biochemistry.... but here for example only reading 'discussion' is insightfull, it elaborates a bit on what you posted

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                • S Offline
                  S Offline
                  Sukkeralf
                  wrote on sidst redigeret af
                  #122

                  yes that also what i goes after - "results", "discussion" or "conclusion" just to get the essence of the article

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                  • S Offline
                    S Offline
                    Sukkeralf
                    wrote on sidst redigeret af
                    #123

                    Skal vi mon lukke over 2300 i dag

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                    • V Offline
                      V Offline
                      Vitus
                      wrote on sidst redigeret af
                      #124

                      Mon dog....

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                      • V Offline
                        V Offline
                        Vitus
                        wrote on sidst redigeret af
                        #125

                        Tegner ikke for godt nu...

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                        • A Offline
                          A Offline
                          AaBforever
                          wrote on sidst redigeret af
                          #126

                          Hvornår mon starter fyrværkeriet...stilheden før stormen? 🙂

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                          • A Offline
                            A Offline
                            AaBforever
                            wrote on sidst redigeret af
                            #127

                            Efter onsdag..måske. Der er ikke så mange ønsker om gode fredags nyheder som i "gamle" dage. 😉

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                            • Legolas23L Offline
                              Legolas23L Offline
                              Legolas23
                              wrote on sidst redigeret af
                              #128

                              Sikke en teaser - 2299

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                              • A Offline
                                A Offline
                                AaBforever
                                wrote on sidst redigeret af
                                #129

                                Nemlig lego...mere kul på..:-D

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                                • V Offline
                                  V Offline
                                  Vitus
                                  wrote on sidst redigeret af
                                  #130

                                  Okay.... vi må prøve at leve med det 🙂

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                                  • Helge_LarsenPI-redaktørH Offline
                                    Helge_LarsenPI-redaktørH Offline
                                    Helge_LarsenPI-redaktør
                                    wrote on sidst redigeret af
                                    #131

                                    Jeg har slettet reklamen for mine mundbind i denne tråd. jeg lægger en regulær bannerannonce op med PI rabat senere i dag eller i morgen.

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                                    • SolsenS Offline
                                      SolsenS Offline
                                      Solsen
                                      wrote on sidst redigeret af
                                      #132

                                      Super

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                                      • E Offline
                                        E Offline
                                        E_L
                                        wrote on sidst redigeret af
                                        #133

                                        Daratumumab (anti-CD38) for treatment of disseminated nontuberculous mycobacteria in a patient with anti-IFN-γ autoantibodies https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa1086/5880009

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                                        • Helge_LarsenPI-redaktørH Offline
                                          Helge_LarsenPI-redaktørH Offline
                                          Helge_LarsenPI-redaktør
                                          wrote on sidst redigeret af
                                          #134

                                          God morgen. 🙂

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