Genmab — August 2020
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JNJ-61178104 was shown to engage its targets, TNF and IL-17A, in systemic circulation measured as drug/target complex formation in normal cynomolgus monkeys (cyno). Surprisingly, quantitative target engagement assessment suggested lower apparent in vivo target-binding affinities for JNJ-61178104 compared to its bivalent parental antibodies, despite their similar in vitro target-binding affinities.
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The target engagement profiles of JNJ-61178104 in humans were in general agreement with the predicted profiles based on cyno data, suggesting similar differences in the apparent in vivo target-binding affinities. These findings show that in vivo target engagement of monovalent bispecific antibody does not necessarily recapitulate that of the molar-equivalent dose of its bivalent parental antibody
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Hvornår mon starter fyrværkeriet...stilheden før stormen?
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Efter onsdag..måske. Der er ikke så mange ønsker om gode fredags nyheder som i "gamle" dage.
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Nemlig lego...mere kul på..:-D
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Jeg har slettet reklamen for mine mundbind i denne tråd. jeg lægger en regulær bannerannonce op med PI rabat senere i dag eller i morgen.
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Daratumumab (anti-CD38) for treatment of disseminated nontuberculous mycobacteria in a patient with anti-IFN-γ autoantibodies https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa1086/5880009
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