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Genmab — Maj 2020

Planlagt Fastgjort Låst Flyttet Genmab
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  • SolsenS Offline
    SolsenS Offline
    Solsen
    wrote on sidst redigeret af
    #1243

    Nice to hear 🙂

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    • E Offline
      E Offline
      E_L
      wrote on sidst redigeret af
      #1244

      4544 / 12 - Multifaceted mechanism of action of DuoHexaBody-CD37 involves both complement- and Fc gamma receptor-mediated cytotoxicity in pre-clinical B-cell lymphoma models https://www.abstractsonline.com/pp8/#!/9045/presentation/7694

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      • E Offline
        E Offline
        E_L
        wrote on sidst redigeret af
        #1245

        JNJ-61186372, an EGFR-cMet bispecific antibody, in EGFR Exon 20 insertion-driven advanced non-small cell lung cancer (NSCLC) https://www.abstractsonline.com/pp8/#!/9045/presentation/5116

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        • E Offline
          E Offline
          E_L
          wrote on sidst redigeret af
          #1246

          JNJ-61186372, an Fc enhanced EGFR/cMet bispecific antibody, mediates EGFR and cMet downmodulation and therapeutic efficacy preclinically through monocyte / macrophage mediated trogocytosis https://www.abstractsonline.com/pp8/#!/9045/presentation/7722

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          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #1247

            JNJ-67571244: A novel anti-CD33 C2 domain binding bispecific antibody with potent T cell redirection activity https://www.abstractsonline.com/pp8/#!/9045/presentation/7733

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            • E Offline
              E Offline
              E_L
              wrote on sidst redigeret af
              #1248

              haven't heard much about the CD33xCD3 duobody yet

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              • S Offline
                S Offline
                Sukkeralf
                wrote on sidst redigeret af
                #1249

                i dont think so

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                • S Offline
                  S Offline
                  Sukkeralf
                  wrote on sidst redigeret af
                  #1250

                  Its funny they promote these newer DuoBodies - not much we hear about JNJ-63709178. 1 or 2 clinical holds so maybe not much to look forward to here

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                  • E Offline
                    E Offline
                    E_L
                    wrote on sidst redigeret af
                    #1251

                    they did double the enrollment size not too long ago though on the -178 , that actually gave me little bit more hope 😉

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                    • E Offline
                      E Offline
                      E_L
                      wrote on sidst redigeret af
                      #1252

                      a few abstracts on BMS-986253
                      at ASCO (talking about something where i think there is not much to look forward to lol)

                      https://meetinglibrary.asco.org/results/986253?page=1

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                      • E Offline
                        E Offline
                        E_L
                        wrote on sidst redigeret af
                        #1253

                        @Mohty_EBMT
                        presented an argument FOR the integration of anti-CD38 antibodies into induction therapies. https://twitter.com/MM_Hub/status/1261257388159635456

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                        • S Offline
                          S Offline
                          Sukkeralf
                          wrote on sidst redigeret af
                          #1254

                          CD20/CD3 - måske postet før:

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                          • S Offline
                            S Offline
                            Sukkeralf
                            wrote on sidst redigeret af
                            #1255

                            Link Preview Image
                            Bispecific Antibodies Poised to Impact Treatment of Lymphoma and Other Blood Cancers

                            favicon

                            (www.ascopost.com)

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                            • BulderB Offline
                              BulderB Offline
                              Bulder
                              wrote on sidst redigeret af
                              #1256

                              Tak sukker. Rart med samling på tingene 🙂

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                              • E Offline
                                E Offline
                                E_L
                                wrote on sidst redigeret af
                                #1257

                                Educational theme | Monoclonal antibodies for the treatment of multiple myeloma https://multiplemyelomahub.com/medical-information/educational-theme-monoclonal-antibodies-for-the-treatment-of-multiple-myeloma

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                                • SolsenS Offline
                                  SolsenS Offline
                                  Solsen
                                  wrote on sidst redigeret af
                                  #1258

                                  ADCs IPO i $19 https://finance.yahoo.com/m/aa62ce39-db78-3b7c-9bda-53e4c6e4d971/adc-therapeutics-prices-ipo.html

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                                  • E Offline
                                    E Offline
                                    E_L
                                    wrote on sidst redigeret af
                                    #1259

                                    https://www.fiercebiotech.com/biotech/what-pandemic-adc-s-233m-listing-biotech-ipos-keep-rolling this has a bit more on Cami

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                                    • K Offline
                                      K Offline
                                      kkjoel
                                      wrote on sidst redigeret af
                                      #1260

                                      Tak EL. Rart med opsummering af mAb feltet/stofferne indenfor MM.. for os der ikke er helt stive i det hele 🙂

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                                      • K Offline
                                        K Offline
                                        kkjoel
                                        wrote on sidst redigeret af
                                        #1261

                                        Fandt nedenståen i securities filingen fra ADC - ikke uinteressant vist, der blev talt om det herinde for nylig (GENs mulighed for at forhandle de 25%). https://www.sec.gov/Archives/edgar/data/1771910/000114036120009738/nt10009045x3_f1.htm

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                                        • K Offline
                                          K Offline
                                          kkjoel
                                          wrote on sidst redigeret af
                                          #1262

                                          "Risks Related to Our Relationship with Third Parties / Our rights to Cami are subject to our collaboration and license agreement with Genmab, and there can be no assurance that we will maintain the rights to develop or commercialize Cami. / Our collaboration and license agreement with Genmab requires a divestment of Cami, in which Genmab has a 25% interest, following 60 days, and no later than 65 days, after the database lock for the Phase 1/2 clinical trial, which occurred on April 2, 2020."

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